Results 261 to 270 of about 381,302 (291)
Some of the next articles are maybe not open access.
Immunocytochemical localization of ubiquitin-activating enzyme in the cell nucleus
Biochemical and Biophysical Research Communications, 1991Ubiquitin-activating enzyme, "E1", is the first enzyme in the pathway leading to formation of ubiquitin-protein conjugates. We present immunocytochemical evidence that Ubiquitin-activating enzyme is concentrated in the cell nucleus. This finding points to the nucleus as the major site of action of this enzyme.
J C, Cook, P B, Chock
openaire +2 more sources
American Journal of Physiology-Cell Physiology, 1993
Ubiquitin, a 76-amino acid protein, is covalently attached to abnormal and short-lived proteins, thus marking them for ATP-dependent proteolysis in eukaryotic cells. Ubiquitin is found within the cytoplasm, nucleus, microvilli, autophagic vacuoles, and lysosomes.
J S, Trausch +4 more
openaire +2 more sources
Ubiquitin, a 76-amino acid protein, is covalently attached to abnormal and short-lived proteins, thus marking them for ATP-dependent proteolysis in eukaryotic cells. Ubiquitin is found within the cytoplasm, nucleus, microvilli, autophagic vacuoles, and lysosomes.
J S, Trausch +4 more
openaire +2 more sources
Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1
Molecular Biology Reports, 2009UBE1 plays an important role in the first step of ubiquitin-proteasome pathway to activate ubiquitin. Both the structure and biochemical property research of human UBE1 protein, and the activity analysis of those enzymes which are related with ubiquitination pathway, are based on high purity of UBE1 protein.
Mei, Zheng +7 more
openaire +2 more sources
The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity
Journal of Functional Foods, 2014 Functional foods targeting the ubiquitin-activating enzyme (E1) of the ubiquitin–proteasome pathway as anti-tumour agents are considered to be important for cancer chemoprevention. The low-toxicity Panax ginseng was used in traditional herbal medicine or food use for either treating or preventing cancer for more than 1000 years.
Tsui-Ling Chang
exaly +3 more sources
Isolation and Characterization of Ubiquitin-activating Enzyme E1-domain Containing 1, UBE1DC1
Molecular Biology Reports, 2005Ubiquitin and other ubiquitin-like proteins play important roles in post-translational modification. They are phylogenetically well-conserved in eukaryotes. Activated by other proteins, ubiquitin and ubiquitin-like proteins can covalently modify target proteins.
T. Dou +7 more
semanticscholar +3 more sources
Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme
Journal of Natural Products, 2002Screening for inhibitors of the ubiquitin-proteasome pathway, considered to regulate important cellular events and linked to serious diseases as well, led to isolation of a new compound, panepophenanthrin, from the fermented broth of a mushroom strain, Panus rudis Fr. IFO 8994.
Ryuichi, Sekizawa +6 more
openaire +2 more sources
Rabbit ubiquitin-activating enzyme E1: cDNA cloning, sequence and expression
Gene, 1997A cDNA clone encoding ubiquitin-activating enzyme E1 has been isolated from a rabbit heart cDNA library and sequenced. The 3.485 kb cDNA contains an open reading frame of 1058 amino acid residues which predicts a protein of approx. 118 kDa. The deduced protein sequence exhibits a very high homology to other ubiquitin-activating enzymes identified in a ...
Sun, B. +3 more
openaire +2 more sources
The gene coding a ubiquitin-activating enzyme may locate on X chromosome
Biochemical and Biophysical Research Communications, 1988tsBN75 cells which have a ts defect in the S phase have a mutation linked to the gene of hypoxanthine phosphoribosyl transferase and cannot complement ts85 cells which have a ts defect in the ubiquitin-activating enzyme. The ubiquitin-activating enzyme may be required for completion of the S phase.
M, Ohtsubo, T, Nishimoto
openaire +2 more sources
Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors
Bioorganic & Medicinal Chemistry Letters, 2018Ubiquitin-activating enzyme (E1), which catalyzes the activation of ubiquitin in the initial step of the ubiquitination cascade, is a potential therapeutic target in multiple myeloma and breast cancer treatment. However, only a few E1 inhibitors have been reported to date.
Yukihiro Itoh, Miki Suzuki
openaire +2 more sources
The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis
Atherosclerosis, 2016The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes. Whether UBA1 participates the development of vascular restenosis remains unknown. This study aims to determine the role of UBA1 in the development of balloon injury induced neointimal ...
Zhexue, Qin +8 more
openaire +2 more sources