Results 211 to 220 of about 7,340,584 (263)

Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus. [PDF]

Elife
Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Heine H, Qian S, Yang J, Pekosz A, Zhang Y, Wang J.   +11 more
europepmc   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

The role of deubiquitinating enzymes and their inhibitors in esophageal carcinoma (Review). [PDF]

Int J Oncol
Zhao Y, He C, Chen K, Sun N, He R, Li G.
europepmc   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging. [PDF]

Cell Mol Life Sci
Sleiman M, Ranti D, Baskaran S, Kreis P, Muth S, Gallrein C, Münster-Wandowski A, Rahnis N, Cirri E, Eickholt BJ, Kirstein J.   +10 more
europepmc   +1 more source

FAM134B Restricts African Swine Fever Virus Capsid Assembly via Reticulophagy and Its Antiviral Activity is Antagonized by the Viral Virulence‐Associated Factor pMGF300‐2R

Advanced Science, EarlyView.
ABSTRACT African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating viral disease in domestic pigs and wild boar. ASFV is a large DNA virus whose capsid assembly takes place within perinuclear viral factories (VFs). Accumulating evidence has demonstrated that reticulophagy confers antiviral activity against multiple RNA ...
Rui Luo, Jing Zhang, Ruojia Huang, Xianfeng Zhang, Lian‐Feng Li, Jing Lan, Zhanhao Lu, Yuan Sun, Tao Wang, Hua‐Ji Qiu   +9 more
wiley   +1 more source

Pathological role of deubiquitinating enzymes in lung cancer: recent insights and advances. [PDF]

Am J Cancer Res
Huang Q, Zhang Z, Wang YN, Li MM, Han XH, Han XJ, Li QG.   +6 more
europepmc   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin-Like Proteins. [PDF]

Angew Chem Int Ed Engl
Chanda S, Liu WR.
europepmc   +1 more source

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage. [PDF]

Nat Commun
Hales LT, Tammiste PM, Walker AJ, Bryce R, Sugden A, Knebel A, Toth R, Lamoliatte F, Péteri M, Curry O, Masson GR, De Cesare V, Maniaci C.   +12 more
europepmc   +1 more source

Fine-Tuning Protein Fate: Mechanisms of E1, E2, and E3 Enzymes and Deubiquitinases in Cell Signaling. [PDF]

Int J Mol Sci
Kim Y, Kim EK, Jang HH.
europepmc   +1 more source