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Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis
Current Topics in Medicinal ChemistryAbstract: Signaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific proteases (USPs) account for the majority of protein deubiquitination activities.
Juzheng Zhang, Zhenran Wang
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Multifunctional regulation and treatment of ubiquitin specific protease 10
Biochemical PharmacologyUSP10 is a critical deubiquitinating enzyme within the ubiquitin-specific protease family, playing multifaceted roles in cellular physiology and disease pathogenesis. Structurally composed of a G3BP1-interacting motif, a N-terminal domain (mediating most protein interactions), and a catalytic USP domain (residues 415-795, catalytic triad C424-H736-D751)
Xiaodong Chen +3 more
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Emerging roles of ubiquitin-specific proteases in the cardiovascular system
Molecular PharmacologyThe universal posttranslational modification ubiquitination was originally discovered in the 1980s as a tag appended to cellular proteins to mark them for degradation by the 26S proteasomal complex. Subsequent discoveries have established ubiquitination as a process that directs spatial and temporal activities of proteins that are integral to all ...
Bipradas Roy +3 more
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Function and regulation of SUMO proteases
Nature Reviews Molecular Cell Biology, 2012Mark Hochstrasser, Christopher M Hickey
exaly
Carboxamides as ubiquitin-specific protease inhibitors
2020GUERIN DAVID +8 more
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