Results 11 to 20 of about 525,256 (308)

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

EMBO Molecular Medicine, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post‐translational modifications controlling virtually all cellular processes.
Simone Fulda, Krishnaraj Rajalingam, Ivan Dikic   +2 more
doaj   +3 more sources

Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]

, 2013
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Azuaga, Ana I., Blackledge, Martin, Bravo, Jerónimo, Buday, Laszlo, Casares, Salvador, Cárdenes, Nayra, Ortega Roldan, Jose L., Ringkjøbing Jensen, Malene, van Nuland, Nico A. J.   +8 more
core   +21 more sources

Generation and physiological roles of linear ubiquitin chains [PDF]

, 2012
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
A Ciechanover, A Degterev, A Hershko, A Hershko, A Hershko, A Varshavsky, B Eisenhaber, B Gerlach, C Tokunaga, CK Ea, CM Pickart, CY Ni, DM Wenzel, DW Abbott, EW Doss-Pepe, F Ikeda, F Ikeda, F Ikeda, F Tokunaga, F Tokunaga, F Van Herreweghe, H HogenEsch, H Walczak, H Zhou, Henning Walczak, I Marin, I Marin, Ivan Dikic, J Peng, JN Dynek, JW Harper, Kazuhiro Iwai, KL Lim, M Karin, O Micheau, P Cohen, P de Bie, P Xu, S Hatakeyama, S Rahighi, T Hunter, T Kirisako, TL Haas, V Nagy, VK Chaugule, Y Sato, Y Ye, YC Lo   +47 more
core   +4 more sources

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. [PDF]

, 2015
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes.
Caddick, S, Chudasama, V, Moody, P, Morgan, RE, Smith, ME   +4 more
core   +1 more source

A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome [PDF]

, 2007
E1 ubiquitin activating enzyme catalyzes the initial step in all ubiquitin-dependent processes. We report the isolation of uba1-204, a temperature-sensitive allele of the essential Saccharomyces cerevisiae E1 gene, UBA1.
Amerik A. Y., Babbitt S. E., Bertolaet B. L., Bertolaet B. L., Biggins S., Chen L., Cheng I. H., Ciechanover A., Deshaies R. J., Deveraux Q., Elsasser S., Elsasser S., Elsasser S., Finley D., Funakoshi M., Gandre S., Glickman M. H., Guthrie C., Haas A. L., Haracska L., Hicke L., Hofmann K., Johnson E. S., Kang Y., Kleijnen M. F., Kulka R. G., Lambertson D., Lambertson D., Lowe E. D., Madura K., McGrath J. P., Nazli Ghaboosi, Ortolan T. G., Peng J., Pickart C. M., Raasi S., Raasi S., Rao H., Raymond J. Deshaies, Richly H., Ryu K. S., Saeki Y., Saeki Y., Saeki Y., Salvat C., Schauber C., Schuberth C., Shimada K., Swanson R., Swanson R., van Nocker S., van Nocker S., Verma R., Verma R., Verma R., Walters K. J., Walters K. J., Watkins J. F., Wilkinson C.R.M., William Tansey   +59 more
core   +2 more sources

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]

, 2008
Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J., Elsasser, Suzanne, Finley, Daniel, Goh, Amanda M., Howley, Peter M., Verma, Rati, Walters, Kylie J.   +6 more
core   +6 more sources

Impact of RSUME Actions on Biomolecular Modifications in Physio-Pathological Processes

Frontiers in Endocrinology, 2022
The small RWD domain-containing protein called RSUME or RWDD3 was cloned from pituitary tumor cells with increasing tumorigenic and angiogenic proficiency.
Mariana Fuertes, Belén Elguero, David Gonilski-Pacin, Florencia Herbstein, Josefina Rosmino, Nicolas Ciancio del Giudice, Manuel Fiz, Lara Falcucci, Eduardo Arzt, Eduardo Arzt   +9 more
doaj   +1 more source

Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]

, 2016
Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core   +1 more source

Comparison of gene expression of metallothioneins, ubiquitin and p53 in fibroblasts from lung and skin of rats of different age

Regulatory Mechanisms in Biosystems, 2015
We studied gene expression of five metallothioneins (MT 1-5), ubiquitin and protein p53 and their products in fibroblasts culture of the skin and lungs of white rats of different ages (2 weeks, 1, 3, and 24 months) and determined its (metallothionein 1-5
Y. G. Kot, E. V. Kot, E. S. Morosova, E. E. Persky, M. A. Gritsenko, N. I. Bulankina   +5 more
doaj   +1 more source

A ubiquitin-related gene signature for predicting prognosis and constructing molecular subtypes in osteosarcoma

Frontiers in Pharmacology, 2022
Background: Ubiquitination is medicated by three classes of enzymes and has been proven to involve in multiple cancer biological processes. Moreover, dysregulation of ubiquitination has received a growing body of attention in osteosarcoma (OS ...
Nan Wei, Nan Wei, Gong Chao-yang, Gong Chao-yang, Zhou Wen-ming, Zhou Wen-ming, Lei Ze-yuan, Lei Ze-yuan, Shi Yong-qiang, Shi Yong-qiang, Zhang Shun-bai, Zhang Shun-bai, Zhang Kai, Zhang Kai, Ma Yan-chao, Ma Yan-chao, Zhang Hai-hong, Zhang Hai-hong   +17 more
doaj   +1 more source