Results 241 to 250 of about 525,256 (308)

Complexes Formed by the K63-Specific Deubiquitinating Enzyme BRCC36: New Promising Therapeutic Targets in Human Disease. [PDF]

Biomolecules
Zhang X, Pang X, Chen Y, Liu Y, Huang JA, Zeng Y.   +5 more
europepmc   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

A UBH-UBX module amplifies p97/VCP's unfolding power to facilitate protein extraction and degradation. [PDF]

Nat Commun
Huo XY, Liu D, Zou R, Li ZP, Li Y, Pan L, Zhang Y, Zhang ZR.   +7 more
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Correction to "Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability". [PDF]

Nucleic Acids Res
europepmc   +1 more source

How <i>Shigella</i> tackles host defences. [PDF]

Elife
Huang Y, Thurston TLM.
europepmc   +1 more source

Structural Basis of Ubiquitin Recognition by Translesion Synthesis DNA Polymerase ι

, 2010
Gaofeng Cui, Robert C. Benirschke, Han-Fang Tuan, Nenad Juranić, Slobodan Macura, Maria Victoria Botuyan, Georges Mer   +6 more
openalex   +2 more sources

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10. [PDF]

J Cell Sci
Roberts JE, Huynh PT, Carale LO, Whiteley AM.   +3 more
europepmc   +1 more source

LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function

, 2019
Alexa Wade, Yan Liu, Maigen Bethea, Eliana Toren, Hubert M. Tse, Chad S. Hunter   +5 more
openalex   +1 more source