Results 241 to 250 of about 519,123 (352)

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, EarlyView.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer. [PDF]

Oncoimmunology
Du J, Fan Y, Fu J, Ge F, Zhu H, Yang S, Dai J, Yuan T, He Q, Yang B, Zhu H, Dong X.   +11 more
europepmc   +1 more source

Mapping the ubiquitin‐binding domains in the p54 regulatory complex subunit of the Drosophila 26S protease [PDF]

, 1997
Lajos Haracska, Andor Udvardy
openalex   +1 more source

PACS‐2 Mitigates NPSC Apoptosis and Intervertebral Disc Degeneration by Preserving MAM Integrity via the SP1/LRRK2/Mfn2 Axis

Advanced Science, EarlyView.
This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang, Jiaqi Wang, Chenhao Zhao, Qiuwei Li, Zhigang Zhang, Huaqing Zhang, Chongyu Jia, Luping Zhou, Yanxin Wang, Yu Chen, Kaixuan Li, Xu Yan, Jie Fang, Haibao Wang, Dandan Wang, Pingping Su, Jingyu Zhang, Zhiwei Chen, Renjie Zhang, Cailiang Shen   +19 more
wiley   +1 more source

Corrigendum: Ribosomal protein L40e fused with a ubiquitin moiety is essential for the vegetative growth, morphological homeostasis, cell cycle progression, and pathogenicity of Cryptococcus neoformans

Frontiers in Microbiology
Jingyu Zhao, Jingyu Zhao, Yali Yang, Yali Yang, Yibin Fan, Jiu Yi, Chao Zhang, Zhongkai Gu, Weihua Pan, Julin Gu, Wanqing Liao, Wei Fang   +11 more
doaj   +1 more source

The dual role of the ubiquitin-proteasome system in photomorphogenesis. [PDF]

Essays Biochem
Zhou H, Deng XW.
europepmc   +1 more source

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence [PDF]

Jack B. Roberts, Olivia Lucy Georgina Boldvig, Guillaume Aubourg, Sai Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin   +6 more
openalex   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

Characterisation of post-translational and transcriptional reprogramming of the immune response to ISAV and IPNV infections in salmon head kidney cells. [PDF]

Front Immunol
Stewart R, Guitián XS, Gervais O, Jin Y, Salisbury SJ, Ballantyne M, Martin SAM, Orosa-Puente B, Robledo D.   +8 more
europepmc   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source