Results 261 to 270 of about 574,104 (383)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

, 1991
Avram Hershko, D Ganoth, John R. Pehrson, Robert E. Palazzo, Lucie Cohen   +4 more
openalex   +1 more source

Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways [PDF]

, 1996
Junya Fujita, Toshimasa Tsujinaka, Masahiko Jano, Chikara Ebisui, Hiroyuki Saito, Asao Katsume, Ken‐ichi Akamatsu, Yoshiyuki Ohsugi, Hitoshi Shiozaki, Morito Monden   +9 more
openalex   +1 more source

The transcription factor CfHac1 regulates the degradation of ubiquitin-mediated ER-associated misfolded proteins and pathogenicity in Colletotrichum fructicola. [PDF]

Stress Biol
Li S, Guo Y, Zhang S, Li H.
europepmc   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.

, 1992
Laura Hoffman, G Pratt, Martin Rechsteiner   +2 more
openalex   +1 more source

A ubiquitin-like protein which is synergistically inducible by interferon-γ and tumor necrosis factor-α [PDF]

, 1999
Shahri Raasi, Gunter Schmidtke, Rita de Giuli, Marcus Groettrup   +3 more
openalex   +1 more source

Emerging roles for E3 ubiquitin ligases in neural development and disease. [PDF]

Front Cell Dev Biol
Hale M, Bashaw GJ.
europepmc   +1 more source

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Nature reviews. Molecular cell biology, 2016
L. Buetow, Danny T. Huang
semanticscholar   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source