Results 261 to 270 of about 305,105 (318)

The impact of post-translational modifications and subcellular localization on NLRP3 inflammasome activation: A systematic review. [PDF]

Cell Commun Signal
Zhang S, Usman M, Wu Q, Gao Y, Fu L, Chu M, Jia C.   +6 more
europepmc   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source

The deubiquitinase USP9X and E3 ligase WWP1 orchestrate IGF2BP2 ubiquitination homeostasis to drive TNBC progression and cisplatin sensitivity. [PDF]

Cell Death Dis
Xia T, Zhao J, Zhang Z, Lu W, Wang Y, Dong X, Sang M, Ju L, Zhang X, Wei J, Ding Q.   +10 more
europepmc   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

The multifaceted role of RNF213 in oncogenesis: current insights and future research directions. [PDF]

Discov Oncol
Kuang G, Ji H, Yang H, Liu H, Sun H, Liu Y.   +5 more
europepmc   +1 more source

K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

Advanced Science, EarlyView.
Under endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). During the UPR, the cohesin complex at the promoter of cell proliferation‐related genes undergoes K29‐linked ubiquitination, recruiting the cohesin release factor WAPL to release cohesin, leading to transcriptional downregulation and inhibition of cell growth ...
Qiushuang Zhang, Xucong Teng, Yicong Dai, Yuncong Wu, Hongwei Hou, Jinghong Li   +5 more
wiley   +1 more source

Cardiomyocyte USP20 alleviates septic cardiomyopathy by deubiquitinating and inhibiting NLRP3 activity. [PDF]

Clin Transl Med
Dai S, Zhang Y, Huang Z, Chen Y, Yang Z, Zheng R, Ye K, Zhong L, Zheng X, Cai X, Huang W.   +10 more
europepmc   +1 more source

Study on the design, synthesis and activity of MDM2/MDMX anti-tumor stapled peptide PROTAC. [PDF]

Sci Rep
Liao X, Guo M, Hu D, Su C, Liao H.
europepmc   +1 more source

HomoPROTAC^Keap1: A new strategy of chemical knockdown of Keap1 for allergic rhinitis. [PDF]

Acta Pharm Sin B
Qi X.
europepmc   +1 more source

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability. [PDF]

Nat Commun
Dürauer S, Kang HS, Wiebeler C, Machida Y, Schnapka DS, Yaneva D, Renz C, Götz MJ, Weickert P, Major AC, Rahmanto AS, Gutenthaler-Tietze SM, Daumann LJ, Beli P, Ulrich HD, Sattler M, Machida YJ, Schwierz N, Stingele J.   +18 more
europepmc   +1 more source