USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang+9 more
wiley +1 more source
Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.
Avram Hershko+4 more
openalex +1 more source
Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways [PDF]
Junya Fujita+9 more
openalex +1 more source
The transcription factor CfHac1 regulates the degradation of ubiquitin-mediated ER-associated misfolded proteins and pathogenicity in Colletotrichum fructicola. [PDF]
Li S, Guo Y, Zhang S, Li H.
europepmc +1 more source
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou+12 more
wiley +1 more source
A ubiquitin-like protein which is synergistically inducible by interferon-γ and tumor necrosis factor-α [PDF]
Shahri Raasi+3 more
openalex +1 more source
Emerging roles for E3 ubiquitin ligases in neural development and disease. [PDF]
Hale M, Bashaw GJ.
europepmc +1 more source
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
L. Buetow, Danny T. Huang
semanticscholar +1 more source
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu+7 more
wiley +1 more source