Results 271 to 280 of about 574,104 (383)

‘ER degradation’ of a mutant yeast plasma membrane protein by the ubiquitin‐proteasome pathway [PDF]

open access: bronze, 1998
Jean‐Marc Galan   +4 more
openalex   +1 more source

Insights into ubiquitin chain architecture using Ub-clipping

open access: yesNature, 2019
Kirby N. Swatek   +7 more
semanticscholar   +1 more source

Antagonistic Ghd7‐OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice

open access: yesAdvanced Science, EarlyView.
The complex centered on Ghd7 binds to numerous carbon and nitrogen metabolism genes on the genome through the corresponding motifs and transactivates the transcriptional expression of these carbon and nitrogen metabolism genes. With the assistance of OsNAC42 and other unknown Ghd7‐interacting proteins, this complex can regulate different metabolic ...
Guangming Lou   +23 more
wiley   +1 more source

Ezetimibe Engineered L14‐8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53‐SAT1‐Induced Ferroptosis

open access: yesAdvanced Science, EarlyView.
L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang   +8 more
wiley   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

open access: yesAdvanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie   +9 more
wiley   +1 more source

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