Results 21 to 30 of about 305,105 (318)
Regulation of ubiquitin and ubiquitin‐like modifiers by phosphorylation [PDF]
The FEBS Journal, 2021 The regulatory influence of ubiquitin is vast, encompassing all cellular processes, by virtue of its central roles in protein degradation, membrane trafficking, and cell signaling. But how does ubiquitin, a 76 amino acid peptide, carry out such diverse, complex functions in eukaryotic cells? Part of the answer is rooted in the high degree of complexity
Nathaniel L. Hepowit +4 more
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The Ubiquitination Machinery of the Ubiquitin System [PDF]
The Arabidopsis Book, 2014 The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as well as proteins that bind to ubiquitinated proteins leading them to their final fate.
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SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
Frontiers in Cell and Developmental Biology, 2021 Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes.
Immacolata Giordano +15 more
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Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma
Frontiers in Cell and Developmental Biology, 2021 Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression ...
Yue Wu +23 more
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Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology
Frontiers in Physiology, 2019 F-box proteins, the substrate recognition subunits of SKP1–CUL1–F-box protein (SCF) E3 ubiquitin ligase complexes, play crucial roles in various cellular events mediated by ubiquitination.
Yukiko Yoshida +2 more
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Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
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In the family with ubiquitin [PDF]
EMBO reports, 2011 The Cold Spring Harbor meeting on ‘The Ubiquitin family’, held in May 2011, brought together scientists from a wide range of fields, all under the common umbrella of ubiquitin and ubiquitin‐like protein structure, function and regulation.
Alexandru, Gabriela +2 more
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Poxvirus Exploitation of the Ubiquitin-Proteasome System
Viruses, 2010 Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been
Alastair Teale +5 more
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, 2011 In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriano Marchese, Adriana Caballero
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Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit +4 more
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