Results 291 to 300 of about 574,104 (383)

The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro. [PDF]

Life Sci Alliance
Wang XS, Jiou J, Cerra A, Cobbold SA, Jochem M, Mak KHT, Corcilius L, Silke J, Payne RJ, Goddard-Borger ED, Komander D, Lechtenberg BC.   +11 more
europepmc   +1 more source

Systematic and quantitative assessment of the ubiquitin-modified proteome.

Molecules and Cells, 2011
Woong Kim, E. Bennett, Edward L. Huttlin, A. Guo, Jing Li, A. Possemato, M. Sowa, R. Rad, J. Rush, M. Comb, J. Harper, S. Gygi   +11 more
semanticscholar   +1 more source

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Comprehensive Ubiquitome Analysis of <i>Nicotiana benthamiana</i> Leaves Infected with Tomato Brown Rugose Fruit Virus. [PDF]

Biology (Basel)
Yang J, Wang D, Zhang B, Chen M, Chen J, Yan F, Rao S.   +6 more
europepmc   +1 more source

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
wiley   +1 more source

Tumour Necrosis Factor Enhances induction by beta-Interferon of a Ubiquitin Cross-reactive Protein

, 1990
Patricia Buckley Ahrens, Françoise Besançon, Sylvie Mémet, Helmut Ankel   +3 more
openalex   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry. [PDF]

Angew Chem Int Ed Engl
Urschbach M, Huhmann S, Appel D, Ferrari L, Vogl D, Martens S, Becker CFW.   +6 more
europepmc   +1 more source

Ubiquitin chain diversity at a glance

Journal of Cell Science, 2016
M. Akutsu, I. Dikič, Anja Bremm
semanticscholar   +1 more source

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source