Results 61 to 70 of about 574,104 (383)

A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]

, 2015
The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core   +2 more sources

The evolving world of ubiquitin: transformed polyubiquitin chains

Biomolecular Concepts, 2016
The regulation of diverse cellular events by proteins that have undergone post-translational modification with ubiquitin is well documented. Ubiquitin can be polymerized and eight types of polyubiquitin chain contribute to the complexity and specificity ...
Morimoto Daichi, Shirakawa Masahiro
doaj   +1 more source

Research Progress of DUB Enzyme in Hepatocellular Carcinoma

Frontiers in Oncology, 2022
According to GLOBOCAN 2021 cancer incidence and mortality statistics compiled by the International Agency for Research on Cancer, hepatocellular carcinoma (HCC) is the most common malignancy in the human liver and one of the leading causes of cancer ...
Jie Zhao, Jie Zhao, Jinhui Guo, Yanan Wang, Qiancheng Ma, Yu Shi, Feng Cheng, Qiliang Lu, Wen Fu, Guangxiong Ouyang, Ji Zhang, Qiuran Xu, Xiaoge Hu, Xiaoge Hu   +13 more
doaj   +1 more source

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation [PDF]

, 2018
The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early-onset Parkinson’s disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to ...
Aguirre, Jacob D., Barber, Kathryn R., Chaugule, Viduth K., Condos, Tara E.C., Dunkerley, Karen M., Freeman, E Aisha, Konermann, Lars, Shaw, Gary S., Walden, Helen, Xiao, Yiming   +9 more
core   +1 more source

Using Ubiquitin Binders to Decipher the Ubiquitin Code [PDF]

Trends in Biochemical Sciences, 2019
Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and involved in nearly all aspects of eukaryote biological function. The reversibility and heterogeneity of Ub chains attached to protein substrates have complicated their isolation, quantification, and characterization.
Mattern M, Sutherland JD, Kadimisetty K, Barrio R, Rodriguez M   +4 more
openaire   +3 more sources

Red blood cell proteomics reveal remnant protein biosynthesis and folding pathways in PIEZO1-related hereditary xerocytosis

Frontiers in Physiology, 2022
Hereditary xerocytosis is a dominant red cell membrane disorder characterized by an increased leak of potassium from the inside to outside the red blood cell membrane, associated with loss of water leading to red cell dehydration and chronic hemolysis ...
Alexis Caulier, Nicolas Jankovsky, Emilie Fleur Gautier, Emilie Fleur Gautier, Emilie Fleur Gautier, Wassim El Nemer, Corinne Guitton, Hakim Ouled-Haddou, François Guillonneau, Patrick Mayeux, Virginie Salnot, Johanna Bruce, Véronique Picard, Véronique Picard, Loïc Garçon, Loïc Garçon, Loïc Garçon   +16 more
doaj   +1 more source

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT [PDF]

, 2011
Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFß-dependent biological outputs such as epithelial–mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase
A Chantry, A Hata, CH Heldin, CS Lutz, D Javelaud, F Bernassola, F Murray-Zmijewski, FJ McDonald, G Pirozzi, H Li, H Xu, H Zhu, HM Xu, J Tazi, J Xu, J Zavadil, L Levy, M Flasza, NJ Foot, NS Raikwar, P Kavsak, P Lönn, PJ Lu, S Bonni, S Danckwardt, S Hong, S M Soond, S Wicks, S Wiesner, S Zhang, T Atsumi, T Mund, TW Nilsen, U Valcourt, V Ellenrieder, W Li   +35 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?

Pathogens, 2020
Human papillomavirus (HPV) E6 and E7 oncoproteins are critical for development and maintenance of the malignant phenotype in HPV-induced cancers. These two viral oncoproteins interfere with a plethora of cellular pathways, including the regulation of ...
Anamaria Đukić, Lucija Lulić, Miranda Thomas, Josipa Skelin, Nathaniel Edward Bennett Saidu, Magdalena Grce, Lawrence Banks, Vjekoslav Tomaić   +7 more
doaj   +1 more source

Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade

Frontiers in Microbiology, 2022
Defining dynamic protein–protein interactions in the ubiquitin conjugation reaction is a challenging research area. Generating peptide aptamers that target components such as ubiquitin itself, E1, E2, or E3 could provide tools to dissect novel features ...
Małgorzata Lisowska, Fiona Lickiss, Maria Gil-Mir, Anne-Sophie Huart, Zuzanna Trybala, Luke Way, Lenka Hernychova, Adam Krejci, Petr Muller, Radovan Krejcir, Igor Zhukow, Przemyslaw Jurczak, Sylwia Rodziewicz-Motowidło, Kathryn Ball, Borivoj Vojtesek, Ted Hupp, Umesh Kalathiya   +16 more
doaj   +1 more source