Results 91 to 100 of about 187,561 (340)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Engineering ubiquitin to modulate the ubiquitin proteosome system [PDF]

Cell Cycle, 2013
(2013). Engineering ubiquitin to modulate the ubiquitin proteosome system. Cell Cycle: Vol. 12, No. 11, pp. 1651-1652.
Sachdev S. Sidhu, Andreas Ernst
openaire   +3 more sources

USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination

EMBO Reports, 2020
Dynamic control of ubiquitination by deubiquitinating enzymes is essential for almost all biological processes. Ubiquitin‐specific peptidase 22 (USP22) is part of the SAGA complex and catalyzes the removal of mono‐ubiquitination from histones H2A and H2B,
Jens Roedig, Lisa Kowald, Thomas Juretschke, R. Karlowitz, Behnaz Ahangarian Abhari, Heiko Roedig, S. Fulda, Petra Beli, Sjoerd J. L. van Wijk   +8 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

LZTR1 is a regulator of RAS ubiquitination and signaling

Science, 2018
Regulation of RAS by ubiquitination The protein LZTR1 is mutated in human cancers and developmental diseases. Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS.
J. Bigenzahn, Giovanna M. Collu, F. Kartnig, Melanie Pieraks, G. Vladimer, L. Heinz, V. Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, V. Blomen, A. Müller, Georg E. Winter, R. Kralovics, T. Brummelkamp, M. Mlodzik, G. Superti-Furga   +17 more
semanticscholar   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

The role of ubiquitination in health and disease

MedComm
Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction.
Yan Liao, Wangzheqi Zhang, Yang Liu, Chenglong Zhu, Zui Zou   +4 more
doaj   +1 more source

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Science, 2018
Regulation of RAS by ubiquitination The protein LZTR1 is mutated in human cancers and developmental diseases. Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS.
M. Steklov, Silvia Pandolfi, M. Baietti, A. Batiuk, P. Carai, P. Najm, Mingzhen Zhang, Hyunbum Jang, Fabrizio Renzi, Yanyan Cai, L. A. Asbagh, Tibor J. Pastor, M. D. Troyer, Michal Simicek, Enrico Radaelli, H. Brems, Eric Legius, Jan Tavernier, Kris Gevaert, Francis Impens, L. Messiaen, L. Messiaen, Ruth Nussinov, Ruth Nussinov, Stephane Heymans, Stephane Heymans, S. Eyckerman, A. Sablina   +27 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles

Genomics, Proteomics & Bioinformatics, 2020
Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Liya Zhu, Han Cheng, Guoqing Peng, Shuansuo Wang, Zhiguo Zhang, Erdong Ni, Xiangdong Fu, Chuxiong Zhuang, Zexian Liu, Hai Zhou   +9 more
doaj