Results 191 to 200 of about 187,561 (340)

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Precision tuning of ABA signaling by ubiquitination of ABA receptors: modulating protein activity and localization. [PDF]

J Exp Bot
Du C, Zhang Z.
europepmc   +1 more source

Ubiquitination of the Human Immunodeficiency Virus Type 1 Env Glycoprotein [PDF]

, 2000
Andreas Bültmann, Josef Eberle, Jürgen Haas   +2 more
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Integrative Multi-Omics Analysis Reveals the Molecular Characteristics, Tumor Microenvironment, and Clinical Significance of Ubiquitination Mechanisms in Lung Adenocarcinoma. [PDF]

Int J Mol Sci
Long D, Xue Y, Yu X, Qin X, Chen J, Luo J, Ma K, Wei L, Li X.   +8 more
europepmc   +1 more source

Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis [PDF]

, 2001
Rebecca Dunn, Linda Hicke
openalex   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

The Role of Protein Ubiquitination in the Onset and Progression of Sepsis. [PDF]

Cells
Chen MY, Liu Y, Fang M.
europepmc   +1 more source

Posttranslational Phosphorylation and Ubiquitination of the Saccharomyces cerevisiae Poly(A) Polymerase at the S/G₂ Stage of the Cell Cycle

, 2000
Neptune Mizrahi, Claire Moore
openalex   +2 more sources

Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination [PDF]

, 2001
Hong Lin, Xiang Y. Liu, Balanehru Subramanian, Alexander Nakeff, Fred Valeriote, Ben D. Chen   +5 more
openalex   +1 more source