Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1
Nature CommunicationsUbiquitination, catalyzed usually by a three-enzyme cascade (E1, E2, E3), regulates various eukaryotic cellular processes. E3 ligases are the most critical components of this catalytic cascade, determining both substrate specificity and ...
Xiangwei Wu +8 more
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Smad Ubiquitination Regulatory Factor 2 Promotes Metastasis of Breast Cancer Cells by Enhancing Migration and Invasiveness [PDF]
, 2009 Chaoyang Jin +5 more
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PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells [PDF]
, 2021 Jin Wook Kang +7 more
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Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Glua1 Ubiquitination in Synaptic Plasticity and Cognitive Functions: Implications for Neurodegeneration [PDF]
Matthew I. Hiskens
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Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Phase separation directs ubiquitination of gene-body nucleosomes
Nature, 2020 Laura D. Gallego +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Role of histone H2A ubiquitination in Polycomb silencing
Nature, 2004 Hengbin Wang +6 more
semanticscholar +1 more source
SLOMO controls AUX1-mediated gravitropism through a non-proteolytic role for AUX1 ubiquitination [PDF]
Ive De Smet +11 more
openalex +1 more source