Results 221 to 230 of about 308,731 (375)

Allosteric mechanism for site-specific ubiquitination of FANCD2

, 2019
Viduth K. Chaugule, Connor Arkinson, Martin L. Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden   +5 more
openalex   +2 more sources

<p>Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation</p>

, 2020
Shiyang Wang, Tianlong Wang, Li Wang, Liansheng Zhong, Kai Li   +4 more
openalex   +2 more sources

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy [PDF]

, 2017
Mengjie Hu, Qiang Luo, Gulimiran Alitongbieke, Shuyi Chong, Chenting Xu, Lei Xie, Xiaohong Chen, Duo Zhang, Yuqi Zhou, Zhaokai Wang, Xiaohong Ye, Lijun Cai, Fang Zhang, Huibin Chen, Fuquan Jiang, Hui Fang, Shanjun Yang, Jie Liu, María T. Díaz‐Meco, Ying Su, Hu Zhou, Jorge Moscat, Xiangzhi Lin, Xiao-kun Zhang   +23 more
openalex   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Deciphering Key Regulatory Roles of Linear Ubiquitination in Cell Fate Determination and Disease. [PDF]

Research (Wash D C)
Huang J, Tao L, Liao J.
europepmc   +1 more source

Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS [PDF]

, 2019
Peter Hsu, Hui Shi, Calvin J. A. Leonen, Jianming Kang, Champak Chatterjee, Ning Zheng   +5 more
openalex   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Ubiquitination-mediated protein homeostasis in cardiovascular diseases: molecular mechanisms and therapeutic opportunities. [PDF]

Am J Cardiovasc Dis
Wang Y, Liu X, Hu Y, Li H, Li Z, Xu H, Cheng L, Qiao Q, Ye X, Zhang H, Song Z, Wang W, Zhang J.   +12 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Targeting ubiquitination in disease and therapy. [PDF]

Signal Transduct Target Ther
Yang X, Lan T, Zhang B, Tao X, Qi W, Xie K, Cai Y, Liu C, Han J, Wu H.   +9 more
europepmc   +1 more source