Results 31 to 40 of about 165,549 (296)
Vaccines, 2021 K48-linked ubiquitination determining antigen degradation and the endosomal recruitments of p97 and Sec61 plays vital roles in dendritic cell (DC) cross-presentation.
Chun Fang Hu +4 more
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mUbiSiDa: a comprehensive database for protein ubiquitination sites in mammals. [PDF]
PLoS ONE, 2014 MOTIVATION: Protein ubiquitination is one of the important post-translational modifications by attaching ubiquitin to specific lysine (K) residues in target proteins, and plays important regulatory roles in many cell processes.
Tong Chen +6 more
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In the family with ubiquitin [PDF]
EMBO reports, 2011 The Cold Spring Harbor meeting on ‘The Ubiquitin family’, held in May 2011, brought together scientists from a wide range of fields, all under the common umbrella of ubiquitin and ubiquitin‐like protein structure, function and regulation.
Alexandru, Gabriela +2 more
openaire +4 more sources
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Cells, 2019 Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
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Non-degradative Ubiquitination of Protein Kinases. [PDF]
PLoS Computational Biology, 2016 Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non ...
K Aurelia Ball +6 more
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Cells, 2022 Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification.
Liat Oss-Ronen, Tzlil Sarusi, Idan Cohen
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, 2011 In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriano Marchese, Adriana Caballero
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Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit +4 more
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International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...]
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Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. [PDF]
PLoS ONE, 2015 Early studies demonstrated the involvement of ubiquitination of the Notch intracellular domain for rapid turnover of the transcriptional complex at Notch target genes. It was shown that this ubiquitination was promoted by the co-activator Mastermind like
Mozhgan Farshbaf +7 more
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