Results 41 to 50 of about 308,731 (375)

Translesion synthesis in mammalian cells [PDF]

, 2006
DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann, Avkin, Avkin, Bienko, Garg, Gibbs, Gibbs, Gibbs, Guo, Haracska, Hoege, Huang, Johnson, Kannouche, Kannouche, King, Lehmann, Lemontt, Ling, Maher, Masutani, Masutani, McCulloch, Murakumo, Nair, Nakajima, Nelson, Nelson, Nelson, Ogi, Ohmori, Pages, Stelter, Tissier, Vidal, Watanabe   +35 more
core   +2 more sources

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans [PDF]

, 2011
Peer reviewedPublisher ...
Alonso-Monge, Amerik, Andaluz, Bachmair, Brown, Brown, Brown, Calderone, Care, Cash, Chauhan, Cheng, Ciechanover, Ciechanover, Ciechanover, Dennison, Enjalbert, Enjalbert, Ernst, Finley, Finley, Fradin, Fraser, Friant, Garcia-Sanchez, Gietz, Glotzer, Gow, Hauser, Hershko, Hochstrasser, Hromatka, Hube, Hwang, Hwang, Jentsch, Jentsch, Johnson, Kaiser, Kim, Kolkman, Kunze, Leberer, Leng, Liu, Lo, Lorenz, Lorenz, MacCallum, MacCallum, Madura, Mavor, Mayor, Miller, Murad, Muratani, Nakayama, Nantel, Nicholls, Odds, Ozkaynak, Paiva, Peng, Radivojac, Rechsteiner, Rodaki, Roig, Roig, Roig, Santt, Saville, Sepulveda, Seyfried, Sherman, Shi, Skrzypek, Smith, Stadtman, Staub, Stead, Stevenson, Sudbery, Swoboda, Tagwerker, Tanaka, Thewes, Vizcaino, Walther, Weissman, Werner-Washburne, Wilson, Wimalasena, Wolf, Yin, Zakikhany   +94 more
core   +2 more sources

Non-degradative Ubiquitination of Protein Kinases. [PDF]

PLoS Computational Biology, 2016
Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non ...
K Aurelia Ball, Jeffrey R Johnson, Mary K Lewinski, John Guatelli, Erik Verschueren, Nevan J Krogan, Matthew P Jacobson   +6 more
doaj   +1 more source

Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease

Cells, 2022
Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modification.
Liat Oss-Ronen, Tzlil Sarusi, Idan Cohen
doaj   +1 more source

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Nature Communications, 2019
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly ...
N. Gassen, Daniela Niemeyer, D. Muth, V. Corman, S. Martinelli, Alwine Gassen, K. Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, F. Holsboer, R. Brack-Werner, M. Boshart, B. Müller-Myhsok, C. Drosten, M. Müller, T. Rein   +18 more
semanticscholar   +1 more source

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

Journal of Experimental Medicine, 2020
Hyper-activation of NLRP3 inflammasomes contributes to the development of endotoxemia, but the molecular mechanisms are poorly defined. Tang et al. demonstrate that sequential ubiquitination of NLRP3 is crucial to keep NLRP3 inflammasomes in check and ...
Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R. M. Pope, Murugesan V. S. Rajaram, A. Amer, B. Ahmer, J. Gunn, D. Wozniak, L. Tao, V. Coppola, Liwen Zhang, W. Langdon, J. Torrelles, S. Lipkowitz, Jian Zhang   +21 more
semanticscholar   +1 more source

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation [PDF]

, 2003
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the ...
Crews, Craig M., Deshaies, Raymond J., Kim, Kyung B., Ransick, Andy, Sakamoto, Kathleen M., Stein, Bernd, Verma, Rati   +6 more
core   +1 more source

Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]

, 2016
Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core   +1 more source

Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. [PDF]

PLoS ONE, 2015
Early studies demonstrated the involvement of ubiquitination of the Notch intracellular domain for rapid turnover of the transcriptional complex at Notch target genes. It was shown that this ubiquitination was promoted by the co-activator Mastermind like
Mozhgan Farshbaf, Mikael J Lindberg, Anh Truong, Zachery Bevens, Elaina Chambers, Angeliki Pournara, Annika E Wallberg, J Brandon White   +7 more
doaj   +1 more source

Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers

International Journal of Molecular Sciences, 2020
The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes.
Hong-Beom Park, Ju-Won Kim, K. Baek
semanticscholar   +1 more source