Results 51 to 60 of about 278,733 (404)

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source

Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]

Biochemistry, 2011
Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Rachel E. Klevit, Jonathan N. Pruneda, Peter S. Brzovic, Kate E. Stoll, Laura Bolton   +4 more
openaire   +3 more sources

Refolding upon force quench and pathways of mechanical and thermal unfolding of ubiquitin [PDF]

Biophysical Journal, 92, 547-561 (2007), 2006
The refolding from stretched initial conformations of ubiquitin (PDB ID: 1ubq) under the quenched force is studied using the Go model and the Langevin dynamics. It is shown that the refolding decouples the collapse and folding kinetics. The force quench refolding times scale as tau_F ~ exp(f_q*x_F/k_B*T), where f_q is the quench force and x_F = 0.96 nm
arxiv   +1 more source

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination. [PDF]

Nat Commun
The K29/K48-linked ubiquitination generated by the cooperative catalysis of E3 ligase Ufd4 and Ubr1 is an enhanced protein degradation signal, in which Ufd4 is responsible for introducing K29-linked ubiquitination to K48-linked ubiquitin chains to ...
Wu X, Ai H, Mao J, Cai H, Liang LJ, Tong Z, Deng Z, Zheng Q, Liu L, Pan M.   +9 more
europepmc   +2 more sources

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. [PDF]

, 2015
Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling.
Aguilar, Berenice, Grimsey, Neil J, Le, Phillip, Nizet, Victor, Puthenveedu, Manojkumar A, Smith, Thomas H, Soohoo, Amanda L, Trejo, JoAnn   +7 more
core   +2 more sources

Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling. [PDF]

PLoS ONE, 2015
Early studies demonstrated the involvement of ubiquitination of the Notch intracellular domain for rapid turnover of the transcriptional complex at Notch target genes. It was shown that this ubiquitination was promoted by the co-activator Mastermind like
Mozhgan Farshbaf, Mikael J Lindberg, Anh Truong, Zachery Bevens, Elaina Chambers, Angeliki Pournara, Annika E Wallberg, J Brandon White   +7 more
doaj   +1 more source

HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis

Frontiers in Immunology, 2021
Ubiquitination is a process that acts upon every step of the HIV replication cycle. The activity, subcellular localization, and stability of HIV dependency factors as well as negative modulators can be affected by ubiquitination.
Sergio Castro-Gonzalez, Sydney Simpson, Yuhang Shi, Yuexuan Chen, Jared Benjamin, Ruth Serra-Moreno   +5 more
doaj   +1 more source

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

Journal of Experimental Medicine, 2020
Hyper-activation of NLRP3 inflammasomes contributes to the development of endotoxemia, but the molecular mechanisms are poorly defined. Tang et al. demonstrate that sequential ubiquitination of NLRP3 is crucial to keep NLRP3 inflammasomes in check and ...
Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R. M. Pope, Murugesan V. S. Rajaram, A. Amer, B. Ahmer, J. Gunn, D. Wozniak, L. Tao, V. Coppola, Liwen Zhang, W. Langdon, J. Torrelles, S. Lipkowitz, Jian Zhang   +21 more
semanticscholar   +1 more source

Dengue Virus Genome Uncoating Requires Ubiquitination [PDF]

, 2016
The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Byk, Laura Andrea, de Maio, Federico Andres, Gamarnik, Andrea Vanesa, Gebhard, Leopoldo German, Iglesias, Nestor Gabriel, Rossi, Mario   +5 more
core   +3 more sources

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Nature Communications, 2019
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly ...
N. Gassen, Daniela Niemeyer, D. Muth, V. Corman, S. Martinelli, Alwine Gassen, K. Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, A. Zannas, Alexander Herrmann, F. Holsboer, R. Brack-Werner, M. Boshart, B. Müller-Myhsok, C. Drosten, M. Müller, T. Rein   +18 more
semanticscholar   +1 more source