Results 61 to 70 of about 308,731 (375)

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination [PDF]

, 2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that ...
Asbagh, Layka Abbasi, Aushev, Vasily N, Baietti, Maria Francesca, Crowther, Jonathan, Lievens, Sam, Martínez García, David, Radaelli, Enrico, Sablina, Anna A, Simicek, Michal, Steklov, Mikhail, Tavernier, Jan   +10 more
core   +1 more source

Ubiquitination and De-Ubiquitination in the Synthesis of Cow Milk Fat: Reality and Prospects

Molecules
Ubiquitination modifications permit the degradation of labelled target proteins with the assistance of proteasomes and lysosomes, which is the main protein degradation pathway in eukaryotic cells.
Rui Gao, Yanni Wu, Yuhao Wang, Zhangping Yang, Yongjiang Mao, Yi Yang, Chunhua Yang, Zhi Chen   +7 more
doaj   +1 more source

PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination. [PDF]

PLoS ONE, 2015
Neurotransmitter transporter ubiquitination is emerging as the main mechanism for endocytosis and sorting of cargo into lysosomes. In this study, we demonstrate PKC-dependent ubiquitination of three different isoforms of the glycine transporter 1 (GlyT1).
Susana P Barrera, Vicente Castrejon-Tellez, Margarita Trinidad, Elisa Robles-Escajeda, Javier Vargas-Medrano, Armando Varela-Ramirez, Manuel Miranda   +6 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Erratum: MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4B^DCAF13 E3 Ligase in Osteosarcoma Cells. [PDF]

Mol Ther Nucleic Acids
Chen Z, Zhang W, Jiang K, Chen B, Wang K, Lao L, Hou C, Wang F, Zhang C, Shen H.   +9 more
europepmc   +2 more sources

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]

, 2014
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen, Karin, Michael, Suddason, Tesha, Wu, Xuefeng   +5 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Regulation of Glucose, Fatty Acid and Amino Acid Metabolism by Ubiquitination and SUMOylation for Cancer Progression

Frontiers in Cell and Developmental Biology, 2022
Ubiquitination and SUMOylation, which are posttranslational modifications, play prominent roles in regulating both protein expression and function in cells, as well as various cellular signal transduction pathways. Metabolic reprogramming often occurs in
Shunqin Zhu, Shunqin Zhu, Hongyu Gu, Hongyu Gu, Cheng Peng, Cheng Peng, Fanwei Xia, Huan Cao, Hongjuan Cui, Hongjuan Cui   +9 more
doaj   +1 more source

Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. [PDF]

, 2018
Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and invasion. Although this may suppress metastasis, the regulation of the
Agarwal, Ekta, Altieri, Dario C., Bryant, Kelly G., Caino, M. Cecilia, Cohen, Andrew R., Gabrilovich, Dmitry I., Kim, Eui Tae, Kossenkov, Andrew V., Languino, Lucia R., Seo, Jae Ho, Speicher, David W., Tang, Hsin-Yao   +11 more
core   +1 more source

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity [PDF]

, 2017
MDM2–MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response, but their use in
A Plechanovová, A Plechanovová, Andreas K Hock, CS Chen, D Migliorini, D Shi, Danny T Huang, DC Scott, DE Christensen, Dominika Kowalczyk, E Branigan, E Meulmeester, Gary J Sibbet, H Dou, H Dou, H Kawai, H Kawai, I Ray-Coquard, J Momand, J Parant, JC Badciong, JD Oliner, JG Sanchez, JN Pruneda, K Itahana, K Linke, Karen H Vousden, KH Khoo, Koji Nomura, L Buetow, L Buetow, L Huang, LA Tollini, LC Storoni, LK Linares, LT Vassilev, M Andreeff, M Argentini, M Bista, M Kostic, Marta Klejnot, MG Koliopoulos, MHG Kubbutat, ML Choong, MS Dai, MS Dai, MV Poyurovsky, MW Jackson, N Minsky, N Zheng, P Dolezelova, P Emsley, P Roxburgh, PD Adams, PS Brzovic, Q Cheng, Q Cheng, Q Ding, R Honda, R Montes de Oca Luna, R Stad, R Stad, RA Finch, RK Geyer, S Iyappan, S Shangary, S Uldrijan, SN Jones, UM Moll, V Pant, W Kabsch, Y Pan   +71 more
core   +1 more source