Results 91 to 100 of about 851 (145)
Structural proteomics of the human ubiquitinome
Abstract The proteasome maintains the integrity of eukaryotic proteomes by selectively degrading ubiquitinated protein substrates. Ubiquitination targets a wide range of substrates for degradation, including translationally stalled nascent chains, misfolded proteins, and properly folded but short-lived proteins destined for regulatory ...
Anushka Jain +7 more
openaire +1 more source
Molecular & Cellular Proteomics, 2019 Huntington's disease is caused by a polyglutamine repeat expansion in the huntingtin protein which affects the function and folding of the protein, and results in intracellular protein aggregates. Here, we examined whether this mutation leads to altered ubiquitination of huntingtin and other proteins in both soluble and insoluble fractions of brain ...
Karen A. Sap +6 more
openaire +2 more sources
Proteomic techniques to probe the ubiquitin landscape [PDF]
, 2015 Protein ubiquitination is a powerful modulator of cellular functions. Classically linked to the degradation of proteins, it also plays a role in intracellular localization, DNA damage response, vesicle fusion events, and the immune and transcriptional ...
Beaudette, P., Dittmar, G., Popp, O.
core +1 more source
Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53 [PDF]
Ubiquitin-specific proteases (USPs) represent the largest class of human deubiquitinases (DUBs) and comprise its phylogenetically most distant members USP53 and USP54, which are annotated as catalytically inactive pseudoenzymes.
Bezstarosti, Karel +10 more
core +4 more sources
CHARACTERIZATION OF POLYUBIQUITIN CHAINS BY MASS SPECTROMETRY [PDF]
, 2016 The work outlined in this dissertation will allow biochemists and cellular biologists to characterize polyubiquitin chains involved in their cellular environment by following a facile mass spectrometric based workflow.
Lee, Amanda Elizabeth
core +1 more source
An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules. [PDF]
, 2018 Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to many biological processes. However, identifying the E3 ligase responsible for these modifications remains a major bottleneck in ubiquitin research.
Bakos, G +6 more
core +3 more sources
Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling [PDF]
Data and materials availability: The raw MS proteomic data, protein and peptide identification (search engine and SIMSI transfer outputs), Swiss-Prot reference database and quantification results, and concentration-response curves from CurveCurator or ...
Abele, M +17 more
core +1 more source
Novel regulators of chromatin response to DNA damage [PDF]
The DNA damage response (DDR) signaling maintains genome stability, thus protecting cells from aging or malignant transformation. DNA damage and following DDR occur in the context of chromatin, and chromatin governs the damage response at multiple levels
Kolobynina, Ksenia G.
core +1 more source
Ubiquitin-mediated Control of Telomere Uncapping Responses [PDF]
In this thesis we aim to gain more insight into how ubiquitination controls responses totelomere dysfunction by studying the roles of proteins from the ubiquitin machinery in the DNA damage response at deprotected telomeres.
Yalcin, Zeliha
core +2 more sources
Integrative Analysis of Omics Data in Animal Models of Coronavirus Infection
Shiyan dongwu yu bijiao yixueObjectiveThis study analyzes the omics data resources in human-infecting coronavirus animal models collected from various public databases, focusing on data distribution, dataset quantity, data types, species, strains, and research content.
WU Yue +7 more
doaj +1 more source