Results 201 to 210 of about 9,904 (211)

Evidence for a digitoxin conjugating UDP-glucuronosyltransferase in the dog

Biochemical Pharmacology, 1987
Liver microsomes of male Beagle dogs contain a form of UDP-glucuronyltransferase which is capable of conjugating digitoxin and its cleavage products digitoxigenin-bisdigitoxoside and digitoxigenin-monodigitoxoside. The highest reaction rates (Vmax 236 pmoles/mg microsomal protein min) were found for digitoxin and digitoxigenin-monodigitoxoside whereas ...
H.F. Benthe, B. Herzfeldt, L. von Meyerinck, Achim Schmoldt   +3 more
openaire   +3 more sources

Synthesis of a potential inhibitor of UDP-glucuronosyltransferase

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract A convenient synthesis of phosphonomethyl 1- O -(2,2,2-triphenyl)ethyl-α-D- gluco -2-heptulopyranosiduronate ( 2 ) is presented. The target compound proved to be an inhibitor of UDP-glucuronosyltransferase in vitro .
G. A. Van Der Marel, Geert-Jan Boons, Daan Noort, N. Blanckaert, N. C. R. Van Straten, Gerard J. Mulder, J. H. Van Boom, X. Bossuyt   +7 more
openaire   +2 more sources

Characterisation and Regulation of UDP-Glucuronosyltransferases

1991
Many drugs, xenobiotics and endogenous compounds are metabolised via common two stage pathway, which was designated as phase 1 (oxidative metabolism) and phase II (conjugation) by Williams (1). Glucuronidation reactions catalysed by the UDP-glucuronosyltransferases (UDPGTs) is arguably the major conjugation system of phase II metabolism. The metabolism
openaire   +2 more sources

The Use of Hepatocytes to Investigate UDP-Glucuronosyltransferases and Sulfotransferases

2010
Since phase II reactions quantitatively represent the most important pathways involved in drug biotransformation, the development and the use of in vitro approaches to predict glucuronidation and sulfation are currently attracting intense interest to assist in the selection of new drug candidates and for the optimization of dosage regimens for ...
Fournel-Gigleux, Sylvie, Coughtrie, Michael W. H., Ouzzine, Mohamed, Magdalou, Jacques   +3 more
openaire   +4 more sources

Choice of detergent for activating UDP-glucuronosyltransferase

Biochemical Society Transactions, 1980
Brij 58 (0.2%, w/v) Deoxycholate (0.23%, w/v) Lubrol 12A9 (0.2%. w/v) Triton X-100 (0.396, w/v) n-Pentane (3.5%. w/v) Non-activated Y = 0.288~ + 0.789 y = 0.292~ + 0.833 y = 0.280~ + 0.760 y = 0.431x+0.101 v = 0.255~ + 0.726 y = 0.258~ + 0 ...
openaire   +3 more sources

UDP-glucuronosyltransferases

Pharmacology & Therapeutics, 1989
B, Burchell, M W, Coughtrie
openaire   +2 more sources

UDP-Glucuronosyltransferase inhibitors

European Journal of Drug Metabolism and Pharmacokinetics, 1998
Zlatina Naydenova, Konstantin Grancharov, Evgeny Golovinsky   +2 more
openaire   +2 more sources

Differential induction and glycosylation of UDP-glucuronosyltransferase

Biochemical Society Transactions, 1984
Peter I. Mackenzie, Ida S. Owens
openaire   +3 more sources

Cellular and Molecular Aspects of Udp-Glucuronosyltransferases

Drug Metabolism Reviews, 1989
Denyse Bagrel, Sylvie Fournel-Gigleux, Gérard Siest, Jacques Magdalou   +3 more
openaire   +3 more sources

The regulation of UDP glucuronosyltransferase expression

Drug Metabolism and Pharmacokinetics, 2017
openaire   +2 more sources