Results 71 to 80 of about 7,973 (164)
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 445-456, February 2026.Aims Pharmacogenetic implementation requires awareness of the state‐of‐the‐art practice of laboratories providing pharmacogenetic testing. This study investigated how pharmacogenetic guidelines and recommendations have been implemented over time by Italian laboratories participating in the external quality assessment (EQA) Pharmaco‐scheme established ...
Rossana Roncato +8 more
wiley +1 more source
Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases
Frontiers in Physiology, 2018 Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the
Yiou Pan +6 more
doaj +1 more source
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System [PDF]
, 2016 Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity ...
Damm, Georg +11 more
core +2 more sources
British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding +24 more
wiley +1 more source
Journal of Lipid Research, 2013 Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang +14 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.ABSTRACT Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives.
Nádia Aguiar Portela Pinheiro +11 more
wiley +1 more source
The clinical application of
Human Genomics, 2010 Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Crigler–Najjar syndrome type II (CNS‐II) is an uncommon cause of persistent unconjugated hyperbilirubinemia resulting from partial deficiency of hepatic UDP‐glucuronosyltransferase activity. We report the case of a 19‐year‐old male who presented with intermittent jaundice since childhood and recent worsening of scleral icterus.
Danish Kumar Goswami +5 more
wiley +1 more source
Acta Medica Iranica, 2013 To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic ...
Mahbod Kaveh +5 more
doaj
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids [PDF]
, 2016 At a population level there is growing evidence for the beneficial effects of dietary flavonoids on health. However there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide inter-individual variability in ...
Cassidy, Aedin, Minihane, Anne-Marie
core +1 more source