Results 51 to 60 of about 60,978 (228)
Structural Basis for the Action Mechanism of Legionella Glycosyltransferase
Small Structures, 2023 Pathogenic bacterium Legionella pneumophila, the causative agent of Legionnaires’ disease, secretes hundreds of effectors into host cells that subvert cell pathways during pathogenesis.
Tao-Tao Chen +8 more
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Nature Communications, 2020 Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase ...
Yue Fu +19 more
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Frontiers in Plant Science, 2019 The Preiss-Handler pathway, which salvages nicotinate (NA) for NAD synthesis, is a conserved biochemical pathway in land plants. We previously demonstrated that various NA conjugations (mainly methylation and glycosylation) shared the NA detoxification ...
Lingyun Liu +6 more
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Molecules, 2021 Traditional glycosyltransferase (GT) activity assays are not easily configured for rapid detection nor for high throughput screening because they rely on radioactive product isolation, the use of heterogeneous immunoassays or mass spectrometry.
Laurie Engel +4 more
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Enzymatic Glycosylation of Nonbenzoquinone Geldanamycin Analogs via Bacillus UDP-Glycosyltransferase [PDF]
Applied and Environmental Microbiology, 2012 ABSTRACT Geldanamycin (GM) is a naturally occurring anticancer agent isolated from several strains of Streptomyces hygroscopicus . However, its potential clinical utility is compromised by its severe toxicity and poor water solubility.
Cheng-Zhu, Wu +5 more
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Life, 2022 The synthesis of secondary metabolites in plants often includes glycosylation modifications. Often, the final step of constructing plant secondary metabolites is completed by glycosylation transferases, which are also involved in many cell processes.
Conglong Lian +6 more
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High level in vivo mucin-type glycosylation in Escherichia coli
Microbial Cell Factories, 2018 Background Increasing efforts have been made to assess the potential of Escherichia coli strains for the production of complex recombinant proteins. Since a considerable part of therapeutic proteins are glycoproteins, the lack of the post-translational ...
Phillipp Mueller +11 more
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Nature Communications, 2019 UGT76G1 is an UDP-glucose dependent glycosyltransferase and a component of the biosynthesis pathway for the natural sugar substitute steviol glycoside.
Ting Yang +12 more
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The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.
Physiological Reviews, 2019 UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endogenous ...
R. Meech +7 more
semanticscholar +1 more source
Journal of Ginseng Research, 2018 Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using ...
Dan-Dan Wang +8 more
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