Results 41 to 50 of about 76,789 (230)

Piscine UDP-glucuronosyltransferase 1B [PDF]

Aquatic Toxicology, 2007
Glucuronidation is an important detoxification pathway for organic pollutants in fish. We report here the isolation and characterisation of UDP-glucuronosyltransferases (UGT) genes from the closely related marine flatfish, plaice (Pleuronectes platessa) and flounder (Platichthys flesus).
Leaver, Michael, Wright, Joy, Hodgson, Paul, Boukouvala, Evridiki, George, Stephen   +4 more
openaire   +3 more sources

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Comunicación entre computadora industrial e interfaz sincrónica - digital

Revista Elektrón
En diversos tipos de industrias conviven sistemas antiguos con sistemas modernos. En el presente escrito se expone el trabajo de diseño de un sistema embebido basado en un microcontrolador para digitalizar un grupo de señales sincrónicas, empaquetarlas ...
Franco Ezequiel Prats, Arnaldo Sosa, Christian Galasso, Adrián Laiuppa   +3 more
doaj   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

EFFECT OF DIFFERENT LEVELS OF UNDEGRADABLE PROTEIN ON THE NUTRIENT DIGESTIBILITY , RUMEN FERMENTATION AND SOME BIOLOGICAL TRAITS IN AWASSI LAMBS. [PDF]

Mesopotamia Journal of Agriculture, 2010
This study was carried out by using 9 Awassi Lambs, 10-12 months of age with average body weight 48.25kg. The lambs were divided into three groups each of three lambs, and fed on one of the three rations which contained different levels of undegradable ...
Sabah A. Shamoon
doaj   +1 more source

La antinomia de la razón práctica como absurdum practicum

Filosofia Unisinos, 2016
Las antinomias de la razón ocupan un lugar destacado en el sistema crítico de Kant. El conflicto de la razón consigo misma es lo que despierta al Profesor de Königsberg del “sueño dogmático” y lo conduce a la elaboración del idealismo trascendental. Sin
Laura Alejandra Pelegrín
doaj   +1 more source

Cryptococcus neoformans UGT1encodes a UDP-Galactose/UDP-GalNAc transporter [PDF]

Glycobiology, 2016
Cryptococcus neoformans, an opportunistic fungal pathogen, produces a glycan capsule to evade the immune system during infection. This definitive virulence factor is composed mainly of complex polysaccharides, which are made in the secretory pathway by reactions that utilize activated nucleotide sugar precursors.
Li, L.X., Ashikov, A.M., Liu, H., Griffith, C.L., Bakker, H., Doering, T.L.   +5 more
openaire   +3 more sources

Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives [PDF]

Carbohydrate Research, 2016
Neisseria meningitidis serogroup A non-hydrolyzing uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase (NmSacA) catalyzes the interconversion between UDP-GlcNAc and uridine 5'-diphosphate-N-acetylmannosamine (UDP-ManNAc). It is a key enzyme involved in the biosynthesis of the capsular polysaccharide [-6ManNAcα1-phosphate-]n of N ...
Zhang, Lei, Muthana, Musleh M, Yu, Hai, McArthur, John B, Qu, Jingyao, Chen, Xi   +5 more
openaire   +4 more sources

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source