Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma [PDF]
Pharmaceuticals, 2023 An Ugi–Zhu three-component reaction (UZ-3CR) coupled in a one-pot manner to a cascade process (N-acylation/aza Diels–Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of pyrrolo[3,4-b]pyridin-5-ones in 20% to 92 ...
Ivette Morales-Salazar +7 more
doaj +4 more sources
Synthesis of BODIPY-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu/cascade reactions and studies of fluorescence response toward viscosity [PDF]
Frontiers in ChemistryA series of seven new meso-phenyl BODIPY-pyrrolo[3,4-b]pyridin-5-one conjugates were synthesized in one experimental step by using a Sc(III)-catalyzed Ugi-Zhu three-component reaction coupled to a cascade sequence (aza Diels-Alder/N-acylation ...
Julio C. Flores-Reyes +8 more
doaj +4 more sources
Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins. [PDF]
RSC Med Chem, 2023 Six polyheterocycles were studied in vitro against human SARS-CoV-2 finding that one of them exhibited significant activity at initial infection stages, showing prophylactic potential. A second one showed both, prophylactic and therapeutic activity.
Morales-Salazar I +11 more
europepmc +3 more sources
Correction: An intramolecular hydrogen bond-promoted "green" Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity. [PDF]
RSC Adv, 2023 Correction for ‘An intramolecular hydrogen bond-promoted “green” Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity’ by Jie Li et al., RSC Adv., 2022, 12, 33175–33179, https://doi.org/10.1039/D2RA04958A.
Li J +5 more
europepmc +2 more sources
Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy [PDF]
Molecules, 2023 A diversity-oriented synthesis (DOS) of two new polyheterocyclic compounds was performed via an Ugi-Zhu/cascade (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration)/click strategy, both step-by-step to optimize all involved ...
Roberto E. Blanco-Carapia +4 more
doaj +2 more sources
Chemistry Proceedings, 2021 The synthesis of five new bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described.
Ivette Morales-Salazar +5 more
doaj +2 more sources
An intramolecular hydrogen bond-promoted "green" Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity. [PDF]
RSC Adv, 2022 We report a “green chemistry”-based Ugi cascade reaction to furnish a series of 2,5-diketopiperazines (through nucleophilic attack of amides upon ketones in Ugi adducts) at moderate-to-good yields.
Li J +5 more
europepmc +2 more sources
Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction. [PDF]
Beilstein J Org Chem, 2020 A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU.
Li Y +8 more
europepmc +2 more sources
Molbank, 2022 The new polyheterocyclic compound 2-benzyl-3-morpholino-7-(thiophen-2-yl)-6-(thiophen-2-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (1) was synthesized via a one-pot process involving an Ugi-Zhu three-component reaction coupled to a cascade aza ...
Ivette Morales-Salazar +3 more
doaj +1 more source
Polymer Chemistry, 2021 Ugi reaction offers opportunities to facilely access unprecedented sequence control and sequence-driven properties in polypeptoids.
Yinuo Zhu, Y. Tao
semanticscholar +1 more source