Results 91 to 100 of about 7,468 (177)

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Passerini- ja Ugi-reaktiot luonnonainesynteesissä

, 2015
Tämän pro gradu -tutkielman kirjallisessa osassa käsitellään Passerini- ja Ugi-reaktioita luonnonainesynteesin näkökulmasta. Lisäksi kirjallisessa osuudessa esitellään luonnonainesynteesejä joissa näitä multikomponenttireaktioita on hyödynnetty ...
Hartikainen, Saara
core   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Psychological health as a mediator in the association between diet and upper gastrointestinal cancer: insights from a large-scale population-based screening project

The Lancet Regional Health. Western Pacific
Background: Upper gastrointestinal (UGI) cancer, including esophageal cancer and gastric cancer, poses a significant global health burden. While unhealthy dietary patterns are recognized risk factors, increasing attention is being paid to the role of ...
Yueying Zhang, Shanrui Ma, Xinqing Li, Shaoming Wang, Wenqiang Wei   +4 more
doaj   +1 more source

Safety and Efficacy of Vedolizumab for the Patients With Gastrointestinal Acute Graft‐Versus‐Host Disease Refractory to Steroid Treatment After Allogeneic Hematopoietic Stem Cell Transplantation: A Real‐World, Retrospective Multicenter Study (VAST Study)

MedComm, Volume 7, Issue 9, September 2026.
This multicenter, real‐world study with a large sample size (i.e., vedolizumab for aGVHD refractory to steroid treatment, VAST study) was designed to identify the safety and efficacy of vedolizumab treatment in patients with steroid‐refractory gastrointestinal acute graft‐versus‐host disease (SR‐GI‐aGVHD). The overall response rates (ORR) on day 28 and
Leqing Cao, Yi Xia, Song Xue, Jianping Zhang, Jiameng Li, Yuewen Wang, Qi Wen, Ze Tian, Jun Kong, Daoxing Deng, Xiaohui Zhang, Yang Cao, Na Xu, Xiaodong Mo   +13 more
wiley   +1 more source

City-civil society dynamics in urban green infrastructure development in Munich: governance features and their impacts

Nature-Based Solutions
Global climate change and urbanization exacerbate challenges like biodiversity loss and environmental injustice. Urban green infrastructure (UGI) offers ecological, social, and economic benefits, fostering resilient and sustainable cities.
Elizaveta Fakirova, Martina van Lierop, Hade Dorst, Stephan Pauleit   +3 more
doaj   +1 more source

Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)

Molecules, 2007
Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj   +1 more source

Topological, Compositional, and Dynamic Information in Chemical Reaction Systems

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Chemical reaction systems transform and organize information encoded in molecular structure, composition and environmental inputs. Reaction topology constrains how information propagates through a network, shaping both compositional outcomes and dynamic responses.
William E. Robinson
wiley   +1 more source

Ugi coupling reaction.

, 2016
The Ugi coupling reaction involves the combination of isocyanide (a), aldehyde (b), amine (c) and carboxylic acid (d) components in a single reaction step to give an α-aminoacyl amide product, as exemplified above for the preparation of AZ126.
Darren S. Heeke (3220149), Martin E. Cooper (2508670), Andrey Tovchigrechko (64098), Eileen Rao (48505), Jennifer C. Woo (707322), Neil Fraser (1840510), Sean K. Maynard (249632), Nicola Williams (565974), David Hornigold (3220152), Li Yu (81651), Sarah King (3220143), Jason D. Marshall (3220146), Christopher McCrae (1840507), Adeline M. Hajjar (127234)   +13 more
core   +1 more source

Upper Gastrointestinal Endoscopy by Pediatric Surgeons: Our Early Experience

Journal of Indian Association of Pediatric Surgeons
Introduction: Pediatric upper gastrointestinal (UGI) endoscopy is an important procedure in the management of gastrointestinal pathologies. Conventionally, it has been the forte of medical gastroenterologists.
Adnan Sayeed, Anand Alladi, Venkatesh Kesarla Lakshmaiah   +2 more
doaj   +1 more source