Results 101 to 110 of about 7,468 (177)

EUS‐Guided Gallbladder Drainage for Acute Cholecystitis in the Western World: Heterogeneity in Current Practice and the Relation With Patient Outcome

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Laparoscopic cholecystectomy is the standard treatment for acute cholecystitis (AC), but some patients are unfit for (immediate) surgery. Endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) using a lumen‐apposing metal stent (LAMS) is increasingly used in this population.
Louis De Wispelaere, Eva Hufkens, Hannah van Malenstein, Wim Laleman, Michiel Bronswijk, Schalk van der Merwe, Roberto Di Mitri, Michele Amata, Daniela Scimeca, Niels G. Venneman, Koen R. Beukema, Alberto Larghi, Antonio Pelegrino, Felice Molinario, Dominiek De Wulf, Elise Devolder, Dennis Yang, Mustafa Arain, Natalie Cosgrove, Muhammad K. Hasan, Maham Hayat, Kambiz Kadkhodayan, Christophe Snauwaert, Roberto Trasolini, Cynthuja Thilakanathan, Shirley Jiang, Douglas G. Adler, Lionel S. D'Souza, Rogier P. Voermans, Anouk G. Overdevest, Roy L. J. Van Wanrooij, Enrique Pérez‐Cuadrado‐Robles, Willem J. Lammers, Pieter Jan de Jonge, Marco J. Bruno, Helena Degroote, Thomas Billiet, Alexander Arlt, Sebastian Stefanovic, Emine Gökce, Ellen Deschepper, Pieter Hindryckx   +41 more
wiley   +1 more source

Reporting of colorectal anastomotic leakage: Worldwide audit of national databases

Colorectal Disease, Volume 28, Issue 9, September 2026.
Abstract Aim Reporting of colorectal anastomotic leakage (CAL) risk factors and outcomes is not standardized worldwide. This study searched a cohort of national surgical registries to assess the scope of CAL‐related elements that are routinely reported. Methods This international audit was conducted between June 2025 and April 2026.
Anne de Wit, Freek Daams, Katherine Lam, Katherine Donovan, Daniela Ramos‐Delgado, Danique J. I. Heuvelings, Nicole D. Bouvy, Nader Francis, Marylise Boutros, Patricia Sylla   +9 more
wiley   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3196-3207, September 2026.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Participation Barriers in Risk-Stratified Endoscopic Screening for Upper GI Cancer: A Mixed-Methods Study

JCO Global Oncology
PURPOSEThe purpose of this study was to identify participation determinants among high-risk individuals in risk-stratified upper GI (UGI) cancer screening.METHODSThis sequential mixed-methods study was conducted in a population-based UGI cancer screening
Zeyu Yan, Lei Chen, Jinbao Ma, Mengfei Liu, Zhen Liu, Mei Li, Man Tat Alexander Ng, Yi Yang, Yine Zhang, Yingying Liang, Kaishi Wang, Yincheng Ma, Xiaoming Ma, Ren Li, Hongrui Tian, Hongchen Zheng, Wenlei Yang, Chao Shi, Yaqi Pan, Huanyu Chen, Zhonghu He, Yang Ke   +21 more
doaj   +1 more source

Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3243-3259, September 2026.
Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng, Gen Li, Man Zhou, Rushil Mandlik, Doris Wang, Yiping Qi   +5 more
wiley   +1 more source

α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions

Beilstein Journal of Organic Chemistry
A small library of bis- and tetraamides was synthesized by the Ugi reaction with α-ketoglutaric acid, tert -butyl isocyanide, aromatic aldehydes, and aromatic amines. When o -azidoanilines were used, azidated peptidomimetics were obtained, the post ...
Vladyslav O Honcharov, Yana I Sakhno, Olena H Shvets, Vyacheslav E Saraev, Svitlana V Shishkina, Tetyana V Shcherbakova, Valentyn A Chebanov   +6 more
openaire   +2 more sources

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3329-3339, September 2026.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

Overcoming the cytosine base editing barrier: Virus‐like particles with uracil‐DNA glycosylase inhibition unlocking the clinical potential

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Yuqing Wu, Xingyu Zhu, Junjie Zhu, Jia Chen, Jiaxu Hong   +4 more
wiley   +1 more source

A novel Cas12b cytosine base editor enables efficient C‐to‐T base editing in the rice genome

Journal of Integrative Plant Biology, Volume 68, Issue 9, Page 3193-3195, September 2026.
The base editor dAaCas12b accurately induces C‐to‐T mutations in rice. It recognizes unique TTTV DNA motifs with a wider editing window, and its optimized guide RNA boosts efficiency, expanding crop gene‐editing resources.
Yulei Wei, Lin He, Jienan Han, Shengnan Ge, Xueheyuan Wang, Xinyu Liu, Jie Deng, Haiyang Zhang, Xinyang Che, Jianfeng Weng, Wujun Ma, Jingyu Xu   +11 more
wiley   +1 more source

Multicomponent Synthesis of Dihydrobenzoxazepinones by Coupling Ugi and Mitsunobu Reactions.

, 2006
Various dihydrobenzo[f ][1,4]oxazepin-5-ones have been convergently prepared in 2–3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 ...
P. LECINSKA, GUANTI, GIUSEPPE, BANFI, LUCA, Renata Riva, Luca Banfi, RIVA, RENATA, BASSO, ANDREA, Andrea Basso Giuseppe Guanti, Paulina Lecinska   +8 more
core   +1 more source