Results 11 to 20 of about 12,153 (191)

Genotyping of UGT1A1*80 as an Alternative to UGT1A1*28 Genotyping in Spain

Pharmaceutics, 2022
Background: The variant rs34983651 (UGT1A1*28) and its genotyping are used to prevent irinotecan-induced toxicity. Several variants are in close linkage disequilibrium.
Adrián Bravo-Gómez, Sara Salvador-Martín, Paula Zapata-Cobo, María Sanjurjo-Sáez, Luis Andrés López-Fernández   +4 more
doaj   +4 more sources

Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ [PDF]

Frontiers in Pharmacology, 2021
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs.
Ya-Di Zhu, Xiao-Qing Guan, Jing Chen, Sheng Peng, Moshe Finel, Ying-Yuan Zhao, Rui-Min Wang, Hui-Chang Bi, Ming Lei, Dan-Dan Wang, Guang-Bo Ge   +10 more
doaj   +2 more sources

ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN [PDF]

Nagoya journal of medical science, 2011
2011-02Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the ...
KATAOKA, RYUJI, MORITA, EMI, KONDO, TAKAAKI, HAMAJIMA, NOBUYUKI, KIMATA, AKIKO, WAKAI, KENJI, HISHIDA, ASAHI, HIROSAWA, NAOKO, OKADA, RIEKO, UEYAMA, JUN, KAWAI, SAYO, NAITO, MARIKO, YAMAMOTO, KANAMI   +12 more
core   +3 more sources

Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients

Scientific Reports, 2018
The aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma ...
Leïla Belkhir, Carole Seguin-Devaux, Laure Elens, Caroline Pauly, Nicolas Gengler, Serge Schneider, Jean Ruelle, Vincent Haufroid, Bernard Vandercam   +8 more
doaj   +2 more sources

Abstract 5032: The relationship between the UGT1A1*27 and UGT1A1*7 genetic polymorphisms and irinotecan-related toxicities in patients with lung cancer [PDF]

Thoracic Cancer, 2017
Background: Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1), UGT1A7, and UGT1A9 genes are associated with interindividual differences in irinotecan toxicities.
Manabu Okumura, Shinnosuke Takemoto, Mitsuko Masutani, Takaya Ikeda, Hiroshi Mukae, Katsumi Nakatomi, Kazuto Ashizawa, Arimori Kazuhiko, Minoru Fukuda, Kazuma Kobayashi, Takuya Honda, Hiroyuki Yamaguchi, Tomomi Iwakiri, Mikio Oka   +13 more
core   +3 more sources

UGT1A1 (TA)n promoter genotype: Diagnostic and population pharmacogenetic marker in Serbia

Balkan Journal of Medical Genetics, 2018
The UGT1A1 enzyme is involved in the metabolism of bilirubin and numerous medications. Unconjugated hyperbilirubinemia, commonly presented as Gilbert syndrome (GS), is a result of decreased activity of the UGT1A1 enzyme, variable number of TA repeats in ...
Vukovic M, Radlovic N, Lekovic Z, Vucicevic K, Maric N, Kotur N, Gasic V, Ugrin M, Stojiljkovic M, Dokmanovic L, Zukic B, Pavlovic S   +11 more
doaj   +2 more sources

Molecular cloning, sequence identification and expression profile of domestic guinea pig (Cavia porcellus) UGT1A1 gene

Biotechnology & Biotechnological Equipment, 2016
Domestic guinea pig is a model animal for human disease research. Uridine diphosphate glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) is an important human disease-related gene. In this study, the complete coding sequence of domestic guinea pig
Yang Deming, An Qingcong, Liu Yonggang
doaj   +2 more sources

Detection of UGT1A1*28 Polymorphism Using Fragment Analysis

Chinese Journal of Lung Cancer, 2017
Background and objective Uridine-diphosphoglucuronosyl transferase 1A1 (UGT1A1), UGT1A1*28 polymorphism can reduce UGT1A1 enzymatic activity, which may lead to severe toxicities in patients who receive irinotecan.
Ying HUANG, Jian SU, Xiaosui HUANG, Danxia LU, Zhi XIE, Suqing YANG, Weibang GUO, Zhiyi LV, Hongsui WU, Xuchao ZHANG   +9 more
doaj   +2 more sources

Profiling of UGT1A1*6, UGT1A1*60, UGT1A1*93, and UGT1A1*28 Polymorphisms in Indonesian Neonates With Hyperbilirubinemia Using Multiplex PCR Sequencing [PDF]

Frontiers in Pediatrics, 2019
Background: Single nucleotide polymorphism (SNP) variants of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene have been studied as an important factor in neonatal hyperbilirubinemia (jaundice) severity. Specific ethnicities, including Asians, have certain SNPs that appear more frequently than others.
Radhian Amandito, Radhian Amandito, Rinawati Rohsiswatmo, Erica Carolina, Rizka Maulida, Windhi Kresnawati, Amarila Malik   +6 more
openaire   +6 more sources

Correlation between UGT1A1 polymorphism and efficacy and toxicity of irinotecan in Chinese cancer patients [PDF]

Frontiers in Pharmacology
ObjectiveTo assess the association between UGT1A1*6/*28 polymorphisms and Irinotecan (IRI) efficacy/toxicity in Chinese cancer patients.MethodWe systematically searched PubMed, Cochrane, CNKI, and Wanfang databases.
Shuai Geng, Yulong Shen, Chen Zhang, Nan Wang, Xinyue Gao, Xinyu Luo, Ning Shi   +6 more
doaj   +2 more sources