Results 21 to 30 of about 12,153 (191)

UGT1A1*28.

, 2023
Wild type (TA6) promotes greater UGT1A1 expression than the mutant UGT1A1*28 (TA7). UGT1A1*28 carriers metabolize irinotecan poorly and are prone to side effects (diarrhea).
Shirou Tsuchida (16747474), Suzune Kodama (16747483), Takashi Aoki (108299), Koji Nakagawa (424076), Noriaki Himi (16747477), Tsugumi Shindo (16747486), Yuuki Miura (16747480)   +6 more
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Compound heterozygous UGT1A1*28 and UGT1A1*6 or single homozygous UGT1A1*28 are major genotypes associated with Gilbert’s syndrome in Chinese Han people

Gene, 2021
Gilbert's syndrome (GS) is a mild condition characterized by periods of hyperbilirubinemia, which results in variations in the UDP-glucuronosyltransferase 1 (UGT1A1) gene. Variant genotypes of UGT1A1 vary in different populations in the world. The present study aimed to determine the genotype of the UGT1A1 promoter and exon that are related to the ...
Meng, Zhang, Hongwu, Wang, Yuancheng, Huang, Xin, Xu, Wei, Liu, Qin, Ning, Tao, Chen, Junying, Qi   +7 more
openaire   +2 more sources

Age and gender distribution among the patients with Gilbert’s syndrome

Фундаментальная и клиническая медицина, 2021
Aim. To analyze age and gender distribution in patients with Gilbert's syndrome.Materials and Methods. We consecutively recruited 115 patients with Gilbert's syndrome. All patients underwent genotyping of the rs8175347 polymorphism within the UGT1A1 gene
A. N. Volkov, E. V. Tsurkan
doaj   +1 more source

Identification of novel UGT1A1 variants including UGT1A1 454C\u3eA through the genotyping of healthy participants of the HPTN 077 study [PDF]

, 2021
Cabotegravir (CAB) is an integrase strand-transfer inhibitor of HIV that has proven effective for HIV treatment and prevention in a long-acting injectable formulation, typically preceded by an oral formulation lead-in phase.
Gordon Chau, Liu, Albert Y., Landovitz, Raphael J, Landovitz, R.J., Eron, Joseph S, Hendrix, Craig W, Cohen, M.S., Irene Kuo, Raphael J. Landovitz, McCauley, M, Seneviratne, Herana Kamal, Joseph J. Eron, Herana Kamal Seneviratne, Landovitz, R J., Grinsztejn, B, Hosseinipour, M C., Allyson N. Hamlin, Bumpus, Namandjé N, Bumpus, Namandjé N., Grinsztejn, B., Cohen, M S., Hosseinipour, Mina C., Leslie Cottle, Cottle, Leslie, Albert Y. Liu, Panchia, R., Seneviratne, Herana Kamal, Li, Sue, Hamlin, A N., Chau, G., Namandjé N. Bumpus, Adeyeye, A., Rinehart, Alex R., Hamlin, A.N., Bumpus, N N., Li, S., Cottle, L, Hamlin, Allyson N., Mccauley, M., Eron, Joseph J., Adeyeye, A, Hendrix, C W., Ravindre Panchia, Dawood, H., Rinehart, A.R., Joseph S. Eron, Hosseinipour, Mina C, Landovitz, Raphael J., Cohen, Myron S., Alex R. Rinehart, Kuo, I., Mina C. Hosseinipour, Halima Dawood, McCauley, Marybeth, Panchia, Ravindre, Beatriz Grinsztejn, Marybeth McCauley, Craig W. Hendrix, Hosseinipour, M.C., Seneviratne, H K., Dawood, Halima, Rinehart, Alex R, Hamlin, Allyson N, Kuo, Irene, Hendrix, Craig W., Chau, Gordon, Eron, J.S., Rinehart, A R., Cohen, Myron S, Bumpus, N.N., Dawood, H, Adeola Adeyeye, Cottle, L., Liu, A.Y., Liu, Albert Y, Grinsztejn, Beatriz, Adeyeye, Adeola, Hendrix, C.W., Seneviratne, H.K., Liu, A Y., Sue Li, Panchia, R, Chau, G, Li, S, Eron, Joseph J, Eron, J S., Myron S. Cohen   +86 more
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Novel combined UGT1A1 mutations in Crigler Najjar Syndrome type I

, 2022
Background Uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1), which is the major UGT1 gene product, is located on chromosome 2q37. The expression of UGT1A1 is relatively managed by a polymorphic dinucleotide repeat inside the promoter TATA box ...
Rebai, Ahmed, Rebai, Ahmed,, Balkiss Abdelmoula, Ahmed Rebai, Nouha Bouayed Abdelmoula, Abdelmoula, Nouha Bouayed, Kharrat, Najla,, Abdellaoui, Nawel,, Nawel Abdellaoui, Rania Abdelhedi, Kharrat, Najla, Bouayed Abdelmoula, Nouha, Abdelhedi, Rania, Abdelmoula, Balkiss,, Najla Kharrat, Mouna Tabebi, Tabebi, Mouna,, Abdelmoula, Balkiss, Abdelhedi, Rania,, Tabebi, Mouna, Abdellaoui, Nawel, Abdelmoula, Nouha Bouayed,   +21 more
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Identification of a UGT1A1*37 Allele in a Korean Patient with Pancreatic Cancer [PDF]

, 2021
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that catalyzes glucuronidation of substances, including bilirubin and other drug metabo lites. Certain UGT1A1 polymorphisms reduce UGT1A1 activity, notably UGT1A1*28 contains thymine-adenine repeats ...
김윤정, 김홍경, 김보연, 이경아   +3 more
core   +1 more source

Linkage disequilibrium of UGT1A1∗6 and UGT1A1∗28 in relation to UGT1A6 and UGT1A7 polymorphisms

Oncology Reports, 2006
UDP-glucuronosyltransferase (UGT) enzymes are responsible for the glucuronidation and detoxification of many endogenous or exogenous xenobiotics. Gilbert's syndrome (GS) and Crigler Najjar syndrome type 2 (CNS-II) are characterized by unconjugated hyperbilirubinemia due to reduced enzymatic activity of UGT1A1.
Naohito, Urawa, Yoshinao, Kobayashi, Jun, Araki, Ryosuke, Sugimoto, Motoh, Iwasa, Masahiko, Kaito, Yukihko, Adachi   +6 more
openaire   +3 more sources

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

Acta Pharmaceutica Sinica B, 2017
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury.
Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong   +7 more
doaj   +1 more source

The importance of the UGT1A1 variants in the development of osteopenia and osteoporosis in postmenopausal women

Scientific Reports, 2021
The UDP-glucuronosyltransferase 1A1 (UGT1A1) is involved in the process of estrogen conjugation and elimination. The aim of the study was to analyze whether the UGT1A1 genetic variants are associated with the development of osteopenia and osteoporosis in
Anna Bogacz, Adam Kamiński, Małgorzata Łochyńska, Izabela Uzar, Jarosław Gorący, Daniel Kotrych, Agnieszka Seremak-Mrozikiewicz, Bogusław Czerny   +7 more
doaj   +1 more source

UGT1A1 genotype-guided dosing of irinotecan: a prospective safety and cost analysis in poor metaboliser patients [PDF]

, 2022
Aim: To determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan.Patients and methods: In this prospective, multicentre, non-randomised study, patients intended for treatment with irinotecan were pre ...
Creemers, G.J., Bins, S., de Man, Femke M., Mathijssen, R.H.J., Hovels, A.M., Laven, Marjan M.J., Mathijssen, Ron H.J., Deenen, Maarten J., Hulshof, Emma C., Houterman, Saskia, Deenen, M.J., Laven, M.M.J., de With, Mirjam, Thijs, Anna M.J., Houtsma, D., Gelderblom, Hans, Schaik, R.H.N. van, McLeod, Howard L., Guchelaar, Henk Jan, Creemers, Geert Jan, van Schaik, Ron H.N., Houterman, S., Koolen, Stijn L.W., Deiman, B.A.L.M., McLeod, H.L., Mathijssen, Ron H.J.; id_orcid, Swen, Jesse J., Koolen, S.L.W., Gelderblom, H., Houtsma, Danny, Thijs, A.M.J., Hövels, Anke M., With, M. de, Guchelaar, H.J., Hulshof, E.C., Swen, J.J., Shulman, K., Deiman, Birgit A.L.M., Shulman, Katerina, Man, F.M. de, Luelmo, S.A.C., Bins, Sander, Luelmo, Saskia A.C.   +42 more
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