Results 71 to 80 of about 70,672 (258)

Carbon ion FLASH irradiation reduces acute skin toxicity compared with conventional dose rate irradiation

Scientific Reports
FLASH radiotherapy, defined by ultra-high dose rates exceeding 40 Gy/s, has shown potential for widening the therapeutic window due to its demonstrated normal tissue-sparing effects while maintaining tumor control with electrons, photons, and protons ...
Yukari Yoshida, Hiromu Suda, Mutsumi Tashiro, Ken Yusa, Masao Nakao, Koichi Ando, Akihisa Takahashi, Tatsuya Ohno   +7 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Hydrated electron yield dependence on instantaneous dose rates with electron ultra-high dose rate (UHDR) irradiation

Physics in Medicine & Biology
Abstract Objective. The aim of this study was to quantify the characteristic transient production yield of hydrated electrons (G-value) in water under ultra-high dose rates (UHDR) with electron irradiation. Changes in this yield with UHDR irradiation may provide insights into the radiation chemistry origins of the ...
Xu Cao, Aubrey Parks, William Thomas, Matthew S Reed, Wesley S Culberson, Brian W Pogue   +5 more
openaire   +2 more sources

MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER

Frontiers in Physics
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy ...
James Cayley, Yaw-Ren E. Tan, Marco Petasecca, Dean Cutajar, Thomas Breslin, Anatoly Rosenfeld, Michael Lerch   +6 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications

Scientific Reports
Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE
L. Whitmore, R. I. Mackay, M. van Herk, P. Korysko, W. Farabolini, A. Malyzhenkov, R. Corsini, R. M. Jones   +7 more
doaj   +1 more source

Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system

Frontiers in Oncology
BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the ...
Jatinder Saini, Jatinder Saini, Danielle P. Johnson Erickson, François Vander Stappen, Matt Ruth, Matt Ruth, Sunan Cui, Sunan Cui, Vanessa Gorman, Séverine Rossomme, Ning Cao, Ning Cao, Eric C. Ford, Eric C. Ford, Juergen Meyer, Juergen Meyer, Charles Bloch, Charles Bloch, Tony Wong, Tony Wong, Clemens Grassberger, Ramesh Rengan, Ramesh Rengan, Jing Zeng, Jing Zeng, Marco Schwarz, Marco Schwarz   +26 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source