Results 61 to 70 of about 70,672 (258)

FLASH effect tissue sparing comparison for X-ray, hadron, and VHEE irradiation modalities

Scientific Reports
FLASH-RT is an irradiation modality using Ultra-High-Dose-Rates, where a healthy tissue sparing effect is observed. Different particle types have distinct characteristics in lateral and distal dose deposition, which can affect the amount of healthy ...
Atia Ibrahimi, Stefan Both, Marc-Jan van Goethem, Francesco Romano, Alexander Gerbershagen   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Experimental characterization of proton minibeam therapy delivery under FLASH dose-rate conditions

Scientific Reports
Proton minibeam radiation therapy (pMBRT) introduces spatial fractionation of dose distributions at submillimeter resolution, offering a promising approach to reducing normal tissue toxicity while maintaining effective tumor control.
Yuting Lin, Wei Wu, Jufri Setianegara, Aoxiang Wang, Nicolas Gerard, Jarrick Nys, Gregory N. Gan, Hao Gao   +7 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Demonstration of ultra-high dose rate electron irradiation at FLASHlab@PITZ

Physics in Medicine & Biology
Abstract Objective. The photo injector test facility at DESY in Zeuthen (PITZ) is building up an R&D platform, known as FLASH lab @PITZ, for systematically studying the FLASH effect in cancer treatment with its high-brightness electron beams, which can provide a uniquely large
X-K Li, Z Amirkhanyan, A Grebinyk, M Gross, Y Komar, F Riemer, A Asoyan, P Boonpornprasert, P Borchert, H Davtyan, D Dmytriiev, M Frohme, A Hoffmann, M Krasilnikov, G Loisch, Z Lotfi, F Müller, M Schmitz, F Obier, A Oppelt, S Philipp, C Richard, G Vashchenko, D Villani, S Worm, F Stephan   +25 more
openaire   +3 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

FLASH radiotherapy: ultra-high dose rates to spare healthy tissue

International Journal of Radiation Biology, 2019
A recent addition to the treatment options in external beam therapy, so-called FLASH radiotherapy, shows remarkable healthy-tissue-sparing properties in a number of pre-clinical studies without impacting the overall treatment efficacy. Its potential in clinical applications is attracting a great deal of interest in the medical community.
openaire   +3 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source