Results 41 to 50 of about 70,672 (258)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

How to increase COVID-19 vaccine uptake among children? determinants associated with vaccine compliance

Frontiers in Pediatrics, 2023
ObjectiveThree aims: to elucidate determinants associated with COVID-19 vaccine uptake in children and the association with parental vaccination; to compare rates of PCR-positive SARS-CoV-2 results between vaccinated and unvaccinated children; to ...
Moshe Hoshen, Moshe Hoshen, Vered Shkalim Zemer, Vered Shkalim Zemer, Shai Ashkenazi, Zachi Grossman, Zachi Grossman, Maya Gerstein, Maya Gerstein, Noga Yosef, Moriya Cohen, Herman Avner Cohen, Herman Avner Cohen   +12 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Silicon carbide sensors in radiotherapy dosimetry: progress, challenges, and perspectives

Frontiers in Sensors
Accurate dosimetry is crucial in radiotherapy and particle therapy to ensure that prescribed doses are delivered to tumors while minimizing damage to healthy tissue. Advanced dosimetry systems are needed to meet the challenges of modern techniques (small
G. Petringa, M. Guarrera, A. Kurmanova, S. Tudisco, C. Verona , C. Verona , G. A. P. Cirrone   +6 more
doaj   +1 more source

Characterizing the resolution and throughput of the Apollo direct electron detector

Journal of Structural Biology: X, 2023
Advances in electron detection have been essential to the success of high-resolution cryo-EM structure determination. A new generation of direct electron detector called the Apollo, has been developed by Direct Electron.
Ruizhi Peng, Xiaofeng Fu, Joshua H. Mendez, Peter S. Randolph, Benjamin E. Bammes, Scott M. Stagg   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Characterization of the PTB ultra-high pulse dose rate reference electron beam

Physics in Medicine & Biology, 2022
Abstract Purpose . This investigation aims to present the characterisation and optimisation of an ultra-high pulse dose rate (UHPDR) electron beam at the PTB facility in Germany. A Monte Carlo beam model has been developed for dosimetry study for future investigation in FLASH radiotherapy and ...
Alexandra Bourgouin, Adrian Knyziak, Marco Marinelli, Rafael Kranzer, Andreas Schüller, Ralf-Peter Kapsch   +5 more
openaire   +4 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm

Radiation Oncology
Background and purpose This study aimed to evaluate whether the clinical prototype of intraoperative electron FLASH radiotherapy (CPIO-EFLASH), with a source-surface distance (SSD) of 50 cm, could achieve ultra-high dose rates, effectively control tumors,
Xiaofei Hao, Huan Du, Binwei Lin, Yang Xia, Mingming Tang, Wei Wu, Decai Wang, Yihan Zhu, Yu Zhang, Jianxin Wang, Yiwei Yang, Dai Wu, Xiaobo Du   +12 more
doaj   +1 more source