Results 31 to 40 of about 70,672 (258)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Key changes in the future clinical application of ultra-high dose rate radiotherapy

Frontiers in Oncology, 2023
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer and retain the anti-tumor effect.
Binwei Lin, Mi Fan, Tingting Niu, Yuwen Liang, Haonan Xu, Wenqiang Tang, Xiaobo Du   +6 more
openaire   +3 more sources

A Review of the Alanine Electron Paramagnetic Resonance Dosimetry Method as a Dose Verification Tool for Low-Dose Electron Beam Applications: Implications on Flash Radiotherapy

Applied Sciences
Alanine dosimetry based on Electron Paramagnetic Resonance (EPR) spectroscopy has been a reliable reference and transfer dosimetry method in high-dose applications, valued for its high precision, accuracy and long-term stability.
Babedi Sebinanyane, Marta Walo, Gregory Campbell Hillhouse, Chamunorwa Oscar Kureba, Urszula Gryczka   +4 more
doaj   +1 more source

LhARA: The Laser-hybrid Accelerator for Radiobiological Applications

Frontiers in Physics, 2020
The “Laser-hybrid Accelerator for Radiobiological Applications,” LhARA, is conceived as a novel, flexible facility dedicated to the study of radiobiology.
Galen Aymar, Tobias Becker, Stewart Boogert, Marco Borghesi, Robert Bingham, Robert Bingham, Ceri Brenner, Philip N. Burrows, Oliver C. Ettlinger, Titus Dascalu, Stephen Gibson, Timothy Greenshaw, Sylvia Gruber, Dorothy Gujral, Claire Hardiman, Jonathan Hughes, W. G. Jones, W. G. Jones, Karen Kirkby, Ajit Kurup, Jean-Baptiste Lagrange, Kenneth Long, Kenneth Long, Wayne Luk, John Matheson, Paul McKenna, Paul McKenna, Ruth McLauchlan, Zulfikar Najmudin, Hin T. Lau, Jason L. Parsons, Jason L. Parsons, Jaroslaw Pasternak, Jaroslaw Pasternak, Juergen Pozimski, Juergen Pozimski, Kevin Prise, Monika Puchalska, Peter Ratoff, Giuseppe Schettino, Giuseppe Schettino, William Shields, Susan Smith, John Thomason, Stephen Towe, Peter Weightman, Colin Whyte, Rachel Xiao   +47 more
doaj   +1 more source

Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy

Scientific Reports, 2023
A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective in curing ...
Ana Lourenço, Anna Subiel, Nigel Lee, Sam Flynn, John Cotterill, David Shipley, Francesco Romano, Joe Speth, Eunsin Lee, Yongbin Zhang, Zhiyan Xiao, Anthony Mascia, Richard A. Amos, Hugo Palmans, Russell Thomas   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cellular irradiations with laser-driven carbon ions at ultra-high dose rates

Physics in Medicine & Biology, 2023
Abstract Objective. Carbon is an ion species of significant radiobiological interest, particularly in view of its use in cancer radiotherapy, where its large Relative Biological Efficiency is often exploited to overcome radio resistance.
Chaudhary, Pankaj, Milluzzo, Giuliana, Mcilvenny, Aodhan, Ahmed, Hamad, Mcmurray, Aaron, Maiorino, Carla, Polin, Kathryn, Romagnani, Lorenzo, Doria, Domenico, Mcmahon, Stephen, Botchway, Stanley, Rajeev, Pattathil, Prise, Kevin, Borghesi, Marco   +13 more
openaire   +4 more sources

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy

Physics and Imaging in Radiation Oncology
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) was negligible in
Celine Karle, Domenico I. Filosa, Mahdi Akbarpour, Nora Schuhmacher, Stephan Brons, Rainer Cee, Christian Schömers, Stefan Scheloske, Kristoffer Petersson, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Thomas Tessonnier, Mahmoud Moustafa, Andrea Mairani, Ivana Dokic   +15 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The sparing effect of ultra-high dose rate irradiation on the esophagus

Frontiers in Oncology
Background and purposeCurrent studies have substantiated the sparing effect of ultra-high dose rate irradiation (FLASH) in various organs including the brain, lungs, and intestines. Whether this sparing effect extends to esophageal tissue remains unexplored.
Wenting Ren, Wenting Ren, Lu Hou, Ke Zhang, Huan Chen, Xin Feng, Ziming Jiang, Fei Shao, Jianrong Dai, Yibo Gao, Yibo Gao, Yibo Gao, Yibo Gao, Jie He, Jie He   +14 more
openaire   +3 more sources