Results 11 to 20 of about 70,672 (258)

The dresden platform is a research hub for ultra-high dose rate radiobiology [PDF]

Scientific Reports, 2023
The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great ...
Josefine Metzkes-Ng, Florian-Emanuel Brack, Florian Kroll, Constantin Bernert, Stefan Bock, Elisabeth Bodenstein, Michael Brand, Thomas E. Cowan, René Gebhardt, Stefan Hans, Uwe Helbig, Felix Horst, Jeannette Jansen, Stephan D. Kraft, Mechthild Krause, Elisabeth Leßmann, Steffen Löck, Jörg Pawelke, Thomas Püschel, Marvin Reimold, Martin Rehwald, Christian Richter, Hans-Peter Schlenvoigt, Ulrich Schramm, Michael Schürer, Joao Seco, Emília Rita Szabó, Marvin E. P. Umlandt, Karl Zeil, Tim Ziegler, Elke Beyreuther   +30 more
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Development of Ultra-High Dose-Rate (FLASH) Particle Therapy

IEEE Transactions on Radiation and Plasma Medical Sciences, 2022
Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy.
Michele M. Kim, Arash Darafsheh, Jan Schuemann, Ivana Dokic, Olle Lundh, Tianyu Zhao, Jose Ramos-Mendez, Lei Dong, Kristoffer Petersson   +8 more
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Diamond detectors for dose and instantaneous dose‐rate measurements for ultra‐high dose‐rate scanned helium ion beams

Medical Physics, 2023
AbstractBackgroundThe possible emergence of the FLASH effect—the sparing of normal tissue while maintaining tumor control—after irradiations at dose‐rates exceeding several tens of Gy per second, has recently spurred a surge of studies attempting to characterize and rationalize the phenomenon. Investigating and reporting the dose and instantaneous dose‐
Tessonnier T., Verona Rinati G., Rank L., Kranzer R., Mairani A., Marinelli M.   +5 more
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Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy [PDF]

International Journal of Radiation Oncology*Biology*Physics, 2020
The National Cancer Institute's Radiation Research Program, in collaboration with the Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy on August 20 and 21, 2018 to bring together experts in experimental and clinical experience in these and related fields.
Griffin, Robert J, Ahmed, Mansoor M, Amendola, Beatriz, Belyakov, Oleg, Bentzen, Søren M, Butterworth, Karl T, Chang, Sha, Coleman, C Norman, Djonov, Valentin, Formenti, Sylvia C, Glatstein, Eli, Guha, Chandan, Kalnicki, Shalom, Le, Quynh-Thu, Loo, Billy W (Jr), Mahadevan, Anand, Massaccesi, Mariangela, Maxim, Peter G, Mohiuddin, Majid, Mohiuddin, Mohammed, Mayr, Nina A, Obcemea, Ceferino, Petersson, Kristoffer, Regine, William, Roach, Mack, Romanelli, Pantaleo, Simone, Charles B (2nd), Snider, James W, Spitz, Douglas R, Vikram, Bhadrasain, Vozenin, Marie-Catherine, Abdel-Wahab, May, Welsh, James, Wu, Xiaodong, Limoli, Charles L   +34 more
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Faster and safer? FLASH ultra-high dose rate in radiotherapy [PDF]

The British Journal of Radiology, 2017
Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy s-1). The "FLASH" radiotherapy maintains tumour control level, suggesting that ultra-high dose rate can substantially enhance the therapeutic window
Durante, Marco, BräUer-Krisch, Elke, Hill, Mark   +2 more
openaire   +3 more sources

Monitoring of Ultra-High Dose Rate Pulsed X-ray Facilities with Radioluminescent Nitrogen-Doped Optical Fiber

Sensors, 2022
We exploited the potential of radiation-induced emissions (RIEs) in the visible domain of a nitrogen-doped, silica-based, multimode optical fiber to monitor the very high dose rates associated with experiments at different pulsed X-ray facilities.
Jeoffray Vidalot, Cosimo Campanella, Julien Dachicourt, Claude Marcandella, Olivier Duhamel, Adriana Morana, David Poujols, Gilles Assaillit, Marc Gaillardin, Aziz Boukenter, Youcef Ouerdane, Sylvain Girard, Philippe Paillet   +12 more
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Transformative Technology for FLASH Radiation Therapy

Applied Sciences, 2023
The general concept of radiation therapy used in conventional cancer treatment is to increase the therapeutic index by creating a physical dose differential between tumors and normal tissues through precision dose targeting, image guidance, and radiation
Reinhard Schulte, Carol Johnstone, Salime Boucher, Eric Esarey, Cameron G. R. Geddes, Maksim Kravchenko, Sergey Kutsaev, Billy W. Loo, François Méot, Brahim Mustapha, Kei Nakamura, Emilio A. Nanni, Lieselotte Obst-Huebl, Stephen E. Sampayan, Carl B. Schroeder, Ke Sheng, Antoine M. Snijders, Emma Snively, Sami G. Tantawi, Jeroen Van Tilborg   +19 more
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Beam Monitors for Tomorrow: The Challenges of Electron and Photon FLASH RT

Frontiers in Physics, 2020
The emergent FLASH RadioTherapy (RT) uses ultrahigh dose-rate irradiation (up to 107 Gy/s instantaneous dose-rate in each μs pulse) to deliver a single high dose of irradiation in a very short time (<200 ms).
Anna Vignati, Anna Vignati, Simona Giordanengo, Federico Fausti, Federico Fausti, Oscar A. Martì Villarreal, Oscar A. Martì Villarreal, Felix Mas Milian, Felix Mas Milian, Giovanni Mazza, Zahra Shakarami, Zahra Shakarami, Roberto Cirio, Roberto Cirio, Vincenzo Monaco, Vincenzo Monaco, Roberto Sacchi, Roberto Sacchi   +17 more
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Stereotactic body radiotherapy for moderately central and ultra-central oligometastatic disease: Initial outcomes

Technical Innovations & Patient Support in Radiation Oncology, 2020
Background: Delivery of SBRT to central thoracic tumours within 2 cm of the proximal bronchial tree (PBT), and especially ultra-central tumours which directly abut the PBT, has been controversial due to concerns about high risk of toxicity and treatment ...
Rosie Cooke, Philip Camilleri, Kwun-Ye Chu, Séan M. O'Cathail, Maxwell Robinson, Frank Van Den Heuvel, Maria A. Hawkins   +6 more
doaj   +1 more source

Radiobiology Experiments With Ultra-high Dose Rate Laser-Driven Protons: Methodology and State-of-the-Art

Frontiers in Physics, 2021
The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index.
Pankaj Chaudhary, Giuliana Milluzzo, Hamad Ahmed, Hamad Ahmed, Boris Odlozilik, Boris Odlozilik, Aaron McMurray, Kevin M. Prise, Marco Borghesi   +8 more
doaj   +1 more source