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Potential Molecular Mechanisms behind the Ultra-High Dose Rate “FLASH” Effect
International Journal of Molecular Sciences, 2022 FLASH radiotherapy, or the delivery of a dose at an ultra-high dose rate (>40 Gy/s), has recently emerged as a promising tool to enhance the therapeutic index in cancer treatment. The remarkable sparing of normal tissues and equivalent tumor control by FLASH irradiation compared to conventional dose rate irradiation—the FLASH effect—has already been
Bogaerts, Eva +3 more
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Applied Sciences, 2023 Charged particle beams driven to ultra-high dose rates (UHDRs) have been shown to offer potential benefits for future clinical applications, particularly in the reduction of normal-tissue toxicity. Studies of the so-called FLASH effect have shown promise,
Sean McCallum +6 more
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Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac
Applied Sciences, 2023 Purpose: The electron linac ElectronFlash installed at Institut Curie (Orsay, France) is entirely dedicated to FLASH irradiation for radiobiological and pre-clinical studies. The system was designed to deliver an ultra-high-dose rate per pulse (UHDR) (above 106 Gy/s) and a very high average dose rate at different energies and pulse durations.
Lucia Giuliano +13 more
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Dosimetry for New Radiation Therapy Approaches Using High Energy Electron Accelerators
Frontiers in Physics, 2020 We have performed dosimetry studies using electron beams with energies up to 50 MeV, which exceed current clinical energy ranges and approaches the bottom end of the very high energy electron range. 50 MeV electron beams can reach deep-seated tumors.
Karolina Kokurewicz +9 more
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Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation [PDF]
Cancers, 2020 Major advances in high precision treatment delivery and imaging have greatly improved the tolerance of radiotherapy (RT); however, the selective sparing of normal tissue and the reduction of neurocognitive side effects from radiation-induced toxicities remain significant problems for pediatric patients with brain tumors.
Yasaman Alaghband +10 more
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Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation [PDF]
International Journal of Radiation Biology, 2021 A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy ...
Houda Kacem +3 more
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Applied SciencesVery-high-energy electrons, coupled with ultra-high dose rates, are being explored for their potential use in radiotherapy to treat deep-seated tumours.
James Cayley +13 more
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In situ correction of recombination effects in ultra-high dose rate irradiations with protons
Physics in Medicine & Biology, 2023 Abstract Background. At the Center for Proton Therapy at the Paul Scherrer Institute (PSI) the delivery of proton radiation is controlled via gas-based ionization chambers: the beam is turned off when a certain amount of preset charge has been collected.
Schaefer, R., Psoroulas, S., Weber, D.C.
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Physics and Imaging in Radiation OncologyBackground and purpose: Very High-Energy Electron (VHEE) radiotherapy stands as a promising alternative to proton therapy in view of the FLASH effect, which allows for differential sparing of healthy tissues under ultra-high dose rate irradiation.
Flavia Gesualdi +7 more
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Radiation Oncology, 2022 Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy ...
Pankaj Chaudhary +22 more
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