Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals [PDF]
Frontiers in Immunology, 2022 Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relatives (Rel) have
Melissa E. Munroe +14 more
doaj +4 more sources
Neural Correlates of Abnormal Temporal Discrimination in Unaffected Relatives of Cervical Dystonia Patients [PDF]
Frontiers in Integrative Neuroscience, 2019 Background: An abnormal temporal discrimination threshold in cervical dystonia (CD) is considered to be a mediational endophenotype; in unaffected relatives it is hypothesized to indicate non-manifesting gene carriage.
Shruti Narasimham +15 more
doaj +7 more sources
Social motor coordination in unaffected relatives of schizophrenia patients: A potential intermediate phenotype [PDF]
Frontiers in Behavioral Neuroscience, 2013 Intermediate endophenotypes emerge as an important concept in the study of schizophrenia. Although research on phenotypes mainly investigated cognitive, metabolic or neurophysiological markers so far, some authors also examined the motor behaviour ...
Jonathan eDel-Monte +15 more
doaj +6 more sources
Sleep and physical activity in patients with newly diagnosed bipolar disorder in remission, their first-degree unaffected relatives and healthy controls [PDF]
International Journal of Bipolar Disorders, 2020 Background Sleep disturbances are a central feature in bipolar disorder (BD) that often persist in remission and seem to be present also in unaffected first-degree relatives (UR) of patients with BD, presenting a possible risk factor for later onset of ...
Nikolaj Folke la Cour Karottki +7 more
doaj +2 more sources
Neurocognitive impairments in unaffected first-degree relatives of schizophrenia
Indian Journal of Psychological Medicine, 2017 Background: Neurocognitive impairments of attention and executive functioning are trait abnormalities in schizophrenia, and these are considered to be endophenotypes. These deficits have been convincingly linked to prefrontal cortical functioning.
Virupaksha Shanmugam Harave +5 more
doaj +4 more sources
Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia [PDF]
Brain Sciences, 2021 The ability to rapidly stop or change a planned action is a critical cognitive process that is impaired in schizophrenia. The current study aimed to examine whether this impairment reflects familial vulnerability to schizophrenia across two experiments ...
Matthew Lehet +6 more
doaj +2 more sources
F188. THALAMIC MICROSTRUCTURE IN UNAFFECTED RELATIVES OF SCHIZOPHRENIA [PDF]
Schizophr Bull, 2018 BACKGROUND: Family, twin, adoption and candidate gene studies all support a genetic component for psychotic disorders. A considerable evidence suggests that the thalamus is abnormal in schizophrenia. The thalamus has a heterogeneous structure with its nucleus having distinct inputs and outputs. Disrupted thalamo-cortical connectivity, in particular, is
Hwang W +4 more
europepmc +3 more sources
Impaired regulation of emotion: neural correlates of reappraisal and distraction in bipolar disorder and unaffected relatives. [PDF]
Transl Psychiatry, 2015 Deficient emotion regulation has been proposed as a crucial pathological mechanism in bipolar disorder (BD). We therefore investigated emotion regulation impairments in BD, the related neural underpinnings and their etiological relevance for the disorder.
Kanske P +3 more
europepmc +4 more sources
Exome sequencing of multiple-sclerosis patients and their unaffected first-degree relatives [PDF]
BMC Research Notes, 2017 Objectives The understanding of complex multifactorial diseases requires the availability of a variety of data for a large-number of affected individuals.
Sheila Garcia-Rosa +11 more
doaj +3 more sources
Abnormal frontoparietal synaptic gain mediating the P300 in patients with psychotic disorder and their unaffected relatives. [PDF]
Hum Brain Mapp, 2017 The “dysconnection hypothesis” of psychosis suggests that a disruption of functional integration underlies cognitive deficits and clinical symptoms. Impairments in the P300 potential are well documented in psychosis.
Díez Á +10 more
europepmc +5 more sources