Results 21 to 30 of about 103,359 (288)

Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling. [PDF]

PLoS ONE, 2012
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity ...
Constantin Fesel, Marta Barreto, Ricardo C Ferreira, Nuno Costa, Lara L Venda, Clara Pereira, Claudia Carvalho, Maria Francisca Morães-Fontes, Carlos M Ferreira, Carlos Vasconcelos, João F Viana, Eugenia Santos, Berta Martins, Jocelyne Demengeot, Astrid M Vicente   +14 more
doaj   +1 more source

Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature. [PDF]

Neurosci Biobehav Rev, 2016
Cardenas SA, Kassem L, Brotman MA, Leibenluft E, McMahon FJ.   +4 more
europepmc   +2 more sources

Transitive inference deficits in unaffected biological relatives of schizophrenia patients [PDF]

Schizophrenia Research, 2016
Currently available treatments have limited efficacy in remediating cognitive impairment in schizophrenia. Efforts to facilitate cognition-enhancing drug discovery recommend the use of varied experimental cognitive paradigms (including relational memory) as assessment tools in clinical drug trials.
Obiora E. Onwuameze, Debra Titone, Beng-Choon Ho   +2 more
openaire   +2 more sources

Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns

Biological Psychiatry Global Open Science, 2022
Background: Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in electroencephalography and functional magnetic resonance imaging studies.
Rosa Grützmann, Christian Kaufmann, Olga A. Wudarczyk, Luisa Balzus, Julia Klawohn, Anja Riesel, Katharina Bey, Michael Wagner, Stephan Heinzel, Norbert Kathmann   +9 more
doaj   +1 more source

Familial hypertrophic cardiomyopathy: vectorcardiographic findings in echocardiographically unaffected relative. [PDF]

Heart, 1982
The electrocardiographic and vectorcardiographic (Frank system) features of the first degree relatives of subjects with documented familial hypertrophic cardiomyopathy were analysed. A total of nine affected members and 29 relatives were examined in four families.
F, Loperfido, R, Fiorilli, A, Digaetano, M, Di Gennaro, P, Santarelli, F, Bellocci, E, Coppola, P, Zecchi   +7 more
openaire   +2 more sources

The distinct features of microbial 'dysbiosis' of Crohn's disease do not occur to the same extent in their unaffected, genetically linked kindred [PDF]

, 2017
Background/Aims: Studying the gut microbiota in unaffected relatives of people with Crohn’s disease (CD) may advance our understanding of the role of bacteria in disease aetiology. Methods: Faecal microbiota composition (16S rRNA gene sequencing),
Bertz, Martin, Calus, Szymon T., Edwards, Christine A., Gaya, Daniel R., Gerasimidis, Konstantinos, Hansen, Richard, Hanske, Laura, Ijaz, Umer Zeeshan, Loman, Nick, McGrogan, Paraic, Quince, Christopher, Russell, Richard K.   +11 more
core   +7 more sources

High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons—Results from a clinical study

European Psychiatry, 2020
BackgroundChanges in inflammatory and metabolic markers are implicated in the pathogenesis in both the development and progression of bipolar disorder (BD).
Marc Østergaard Nielsen, Nanna Aagaard Petersen, Klara Coello, Sharleny Stanislaus, Sigurd A. Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Ruth Frikke-Schmidt, Roger S. McIntyre, Maj Vinberg, Lars Vedel Kessing   +10 more
doaj   +1 more source

An ex vivo test to investigate genetic factors conferring susceptibility to atypical haemolytic uremic syndrome

Frontiers in Immunology, 2023
IntroductionComprehensive genetic analysis is essential to clinical care of patients with atypical haemolytic uremic syndrome (aHUS) to reinforce diagnosis, and to guide treatment.
Sara Gastoldi, Sistiana Aiello, Miriam Galbusera, Matteo Breno, Marta Alberti, Elena Bresin, Caterina Mele, Rossella Piras, Lucia Liguori, Donata Santarsiero, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +1 more source

Neural endophenotypes and predictors of laryngeal dystonia penetrance and manifestation

Neurobiology of Disease, 2021
Focal dystonias are the most common forms of isolated dystonia; however, the etiopathophysiological signatures of disorder penetrance and clinical manifestation remain unclear. Using an imaging genetics approach, we investigated functional and structural
Sanaz Khosravani, Gang Chen, Laurie J. Ozelius, Kristina Simonyan   +3 more
doaj   +1 more source

Pro-inflammatory cytokine alterations in unaffected first-degree relatives of schizophrenia patients

European Psychiatry, 2021
Introduction A growing body of evidence in both chronic and first-episode schizophrenia report increased expression of pro-inflammatory substances in the blood and cerebrospinal fluid of patients.
A. Kurtulmus
doaj   +1 more source