Results 11 to 20 of about 491,727 (238)

Neural Correlates of Abnormal Temporal Discrimination in Unaffected Relatives of Cervical Dystonia Patients [PDF]

Frontiers in Integrative Neuroscience, 2019
Background: An abnormal temporal discrimination threshold in cervical dystonia (CD) is considered to be a mediational endophenotype; in unaffected relatives it is hypothesized to indicate non-manifesting gene carriage.
Richard B. Reilly, Rebecca Beck, Michael Hutchinson   +2 more
exaly   +6 more sources

Brain-Derived Neurotrophic Factor Levels in Newly Diagnosed Patients With Bipolar Disorder, Their Unaffected First-Degree Relatives and Healthy Controls

BJPsych Open, 2021
Background Brain-derived neurotrophic factor (BDNF), which facilitates neuroplasticity and synaptogenesis, may be decreased in bipolar disorder, but has not been systematically investigated in people with newly diagnosed bipolar disorder and unaffected ...
Nanna Petersen, Hanne Lie Kjærstad, Lars Vedel Kessing   +2 more
exaly   +4 more sources

Social motor coordination in unaffected relatives of schizophrenia patients: A potential intermediate phenotype [PDF]

Frontiers in Behavioral Neuroscience, 2013
Intermediate endophenotypes emerge as an important concept in the study of schizophrenia. Although research on phenotypes mainly investigated cognitive, metabolic or neurophysiological markers so far, some authors also examined the motor behaviour ...
Jonathan eDel-Monte, Jonathan eDel-Monte, Delphine eCapdevielle, Delphine eCapdevielle, Manuel eVarlet, Ludovic eMarin, Richard C Schmidt, Robin N Salesse, Benoît Gaël Bardy, Benoît Gaël Bardy, jean-Philippe eBoulenger, jean-Philippe eBoulenger, Marie Christine eGély-Nargeot, Jérôme eAttal, Stéphane eRaffard, Stéphane eRaffard   +15 more
doaj   +4 more sources

Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies [PDF]

Neuropsychiatric Disease and Treatment, 2017
Bo Xiao, Shuai Wang, Jianbo Liu, Tiantian Meng, Yuqiong He, Xuerong Luo Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on ...
Xiao B, Wang S, Liu J, Meng T, He Y, Luo X   +5 more
doaj   +3 more sources

Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals [PDF]

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relatives (Rel) have
Melissa E. Munroe, Kendra A. Young, Joel M. Guthridge, Joel M. Guthridge, Diane L. Kamen, Gary S. Gilkeson, Michael H. Weisman, Mariko L. Ishimori, Daniel J. Wallace, David R. Karp, John B. Harley, Jill M. Norris, Judith A. James, Judith A. James, Judith A. James   +14 more
doaj   +2 more sources

Sleep and physical activity in patients with newly diagnosed bipolar disorder in remission, their first-degree unaffected relatives and healthy controls [PDF]

International Journal of Bipolar Disorders, 2020
Background Sleep disturbances are a central feature in bipolar disorder (BD) that often persist in remission and seem to be present also in unaffected first-degree relatives (UR) of patients with BD, presenting a possible risk factor for later onset of ...
Nikolaj Folke la Cour Karottki, Klara Coello, Sharleny Stanislaus, Sigurd Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Lars Vedel Kessing, Maj Vinberg   +7 more
doaj   +2 more sources

Similar and different grey matter deficits in schizophrenia patients and their unaffected biological relatives [PDF]

Frontiers in Psychiatry, 2013
Neuroimaging studies have revealed significant reductions in the grey matter of several brain regions in patients with schizophrenia, a neuropsychiatric disorder with high hereditability.
Yuan eXiao, Su eLui, Wenjing eZhang, Li eYao, Qiyong eGong   +4 more
doaj   +2 more sources

Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia [PDF]

Brain Sciences, 2021
The ability to rapidly stop or change a planned action is a critical cognitive process that is impaired in schizophrenia. The current study aimed to examine whether this impairment reflects familial vulnerability to schizophrenia across two experiments ...
Matthew Lehet, Ivy F. Tso, Sohee Park, Sebastiaan F. W. Neggers, Ilse A. Thompson, Rene S. Kahn, Katharine N. Thakkar   +6 more
doaj   +2 more sources

Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder

Brazilian Journal of Psychiatry, 2016
Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease.
Fabiano G. Nery, Alexandre D. Gigante, Jose A. Amaral, Francy B. Fernandes, Mariangeles Berutti, Karla M. Almeida, Laura Stertz, Giovana Bristot, Flavio Kapczinski, Beny Lafer   +9 more
doaj   +2 more sources

Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling. [PDF]

PLoS ONE, 2012
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity ...
Constantin Fesel, Marta Barreto, Ricardo C Ferreira, Nuno Costa, Lara L Venda, Clara Pereira, Claudia Carvalho, Maria Francisca Morães-Fontes, Carlos M Ferreira, Carlos Vasconcelos, João F Viana, Eugenia Santos, Berta Martins, Jocelyne Demengeot, Astrid M Vicente   +14 more
doaj   +3 more sources