Results 11 to 20 of about 104,266 (277)

Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder [PDF]

Brazilian Journal of Psychiatry, 2016
Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease.
Fabiano G. Nery, Alexandre D. Gigante, Jose A. Amaral, Francy B. Fernandes, Mariangeles Berutti, Karla M. Almeida, Laura Stertz, Giovana Bristot, Flavio Kapczinski, Beny Lafer   +9 more
doaj   +5 more sources

Default Mode Network Aberrant Connectivity Associated with Neurological Soft Signs in Schizophrenia Patients and Unaffected Relatives [PDF]

Frontiers in Psychiatry, 2018
Brain connectivity and neurological soft signs (NSS) are reportedly abnormal in schizophrenia and unaffected relatives, suggesting they might be useful neurobiological markers of the illness.
Liliana Galindo, Liliana Galindo, Daniel Bergé, Daniel Bergé, Daniel Bergé, Graham K. Murray, Graham K. Murray, Graham K. Murray, Anna Mané, Anna Mané, Anna Mané, Antonio Bulbena, Antonio Bulbena, Victor Pérez, Victor Pérez, Victor Pérez, Oscar Vilarroya, Oscar Vilarroya   +17 more
doaj   +2 more sources

Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives. [PDF]

Clin Exp Immunol, 2017
Forkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain].
Costa N, Marques O, Godinho SI, Carvalho C, Leal B, Figueiredo AM, Vasconcelos C, Marinho A, Moraes-Fontes MF, Gomes da Costa A, Ponte C, Campanilho-Marques R, Cóias T, Martins AR, Viana JF, Lima M, Martins B, Fesel C.   +17 more
europepmc   +3 more sources

Abnormalities of localized connectivity in schizophrenia patients and their unaffected relatives: a meta-analysis of resting-state functional magnetic resonance imaging studies [PDF]

Neuropsychiatric Disease and Treatment, 2017
Bo Xiao, Shuai Wang, Jianbo Liu, Tiantian Meng, Yuqiong He, Xuerong Luo Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on ...
Xiao B, Wang S, Liu J, Meng T, He Y, Luo X   +5 more
doaj   +2 more sources

Anterior cingulate cortico-hippocampal dysconnectivity in unaffected relatives of schizophrenia patients: a stochastic dynamic causal modeling study [PDF]

Frontiers in Human Neuroscience, 2016
Familial risk plays a significant role in the etiology of schizophrenia (SZ). Many studies using neuroimaging have demonstrated structural and functional alterations in relatives of SZ patients, with significant results found in diverse brain regions ...
Yi-Bin Xi, Chen Li, Long-Biao Cui, Jian Liu, Fan Guo, Liang Li, Ping Tian, Ting-Ting Liu, Kang Liu, Gang Chen, Gang Chen, Min Xi, Hua-Ning Wang, Hong Yin   +13 more
doaj   +2 more sources

Associations between childhood maltreatment and oxidative nucleoside damage in affective disorders

European Psychiatry, 2022
Background Childhood maltreatment is an established risk factor for incident unipolar disorder and bipolar disorder. It is separately observed that affective disorders (AD) are also associated with higher nucleoside damage by oxidation.
Johanne Kofod Damm Eriksen, Klara Coello, Sharleny Stanislaus, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Roger S. McIntyre, Maria Faurholt-Jepsen, Kamilla K. Miskowiak, Henrik Enghusen Poulsen, Lars Vedel Kessing, Maj Vinberg   +10 more
doaj   +1 more source

Brain-derived neurotrophic factor levels in newly diagnosed patients with bipolar disorder, their unaffected first-degree relatives and healthy controls

BJPsych Open, 2021
Background Brain-derived neurotrophic factor (BDNF), which facilitates neuroplasticity and synaptogenesis, may be decreased in bipolar disorder, but has not been systematically investigated in people with newly diagnosed bipolar disorder and unaffected ...
Nanna Aagaard Petersen, Marc Østergaard Nielsen, Klara Coello, Sharleny Stanislaus, Sigurd Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Roger S. McIntyre, Ruth Frikke-Smith, Maj Vinberg, Lars Vedel Kessing   +10 more
doaj   +1 more source

Impulsivity in unaffected adolescent biological relatives of schizophrenia patients [PDF]

Journal of Psychiatric Research, 2018
Although schizophrenia is not a prototypic impulse-control disorder, patients report more impulsive behaviors, have higher rates of substance use, and show dysfunction in brain circuits that underlie impulsivity. We investigate impulsivity in unaffected biological relatives of schizophrenia patients to further understand the relationships between ...
Beng-Choon, Ho, Amy B, Barry, Julie A, Koeppel   +2 more
openaire   +2 more sources

Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling. [PDF]

PLoS ONE, 2012
In human systemic lupus erythematosus (SLE), diverse autoantibodies accumulate over years before disease manifestation. Unaffected relatives of SLE patients frequently share a sustained production of autoantibodies with indiscriminable specificity ...
Constantin Fesel, Marta Barreto, Ricardo C Ferreira, Nuno Costa, Lara L Venda, Clara Pereira, Claudia Carvalho, Maria Francisca Morães-Fontes, Carlos M Ferreira, Carlos Vasconcelos, João F Viana, Eugenia Santos, Berta Martins, Jocelyne Demengeot, Astrid M Vicente   +14 more
doaj   +1 more source

Transitive inference deficits in unaffected biological relatives of schizophrenia patients [PDF]

Schizophrenia Research, 2016
Currently available treatments have limited efficacy in remediating cognitive impairment in schizophrenia. Efforts to facilitate cognition-enhancing drug discovery recommend the use of varied experimental cognitive paradigms (including relational memory) as assessment tools in clinical drug trials.
Obiora E. Onwuameze, Debra Titone, Beng-Choon Ho   +2 more
openaire   +2 more sources