Results 101 to 110 of about 3,589 (156)

THY1 is a conserved marker of undifferentiated spermatogonia in the pre-pubertal bull testis [PDF]

REPRODUCTION, 2010
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation.
Suzanne C, Reding, Aaron L, Stepnoski, Elizabeth W, Cloninger, Jon M, Oatley   +3 more
openaire   +2 more sources

Testicular expression of the Lin28/let-7 system: hormonal regulation and changes during postnatal maturation and after manipulations of puberty [PDF]

, 2015
[Abstract] The Lin28/let-7 system, which includes the RNA-binding proteins, Lin28a/Lin28b, and let-7 miRNAs, has emerged as putative regulator of puberty and male gametogenesis; yet, its expression pattern and regulation in postnatal testis remain ill ...
Cordido, Fernando, Gaytán, Francisco, León, Silvia, Manfredi-Lozano, María, Morales, Concepción, Pinilla, Leonor, Ruiz-Pino, Francisco, Sangiao-Alvarellos, Susana, Tena-Sempere, Manuel   +8 more
core   +2 more sources

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, Volume 13, Issue 6, Page 1575-1591, September 2025.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner

Communications Biology
Post-transcriptional regulation mediated by RNA binding proteins is crucial for male germline development. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), an RNA binding protein, is specifically expressed in human and mouse male gonads and
Jiaqiang Luo, Chao Yang, Shuai Xu, Zhiyong Ji, Yuxiang Zhang, Haowei Bai, Zhiwen Deng, Jiayi Liang, Yuhua Huang, Erlei Zhi, Ruhui Tian, Peng Li, Fujun Zhao, Zhi Zhou, Zheng Li, Chencheng Yao   +15 more
doaj   +1 more source

Beyond the Binary: Controlling Natural Sex‐Change in Hermaphroditic Fishes

Reviews in Aquaculture, Volume 17, Issue 4, September 2025.
ABSTRACT Sex‐change in hermaphroditic fishes is a complex but natural biological phenomenon that has significant implications for aquaculture fingerling production, selective breeding, and grow‐out. Understanding the physiological, endocrinological, and molecular pathways underlying hermaphroditism in fishes offers unique opportunities to manipulate ...
Roni Chandra Mondal, Jarrod L. Guppy, Maria A. Villacis‐Escobar, Dean R. Jerry   +3 more
wiley   +1 more source

Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas

Andrology, Volume 13, Issue 5, Page 1213-1222, July 2025.
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer, Lucas Klaus, Sybille D. Reichardt, Alexander Fichtner, Holger M. Reichardt   +4 more
wiley   +1 more source

Sex Reversal in Zebrafish fancl Mutants is Caused by Tp53-Mediated Germ Cell Apoptosis [PDF]

, 2013
The molecular genetic mechanisms of sex determination are not known for most vertebrates, including zebrafish. We identified a mutation in the zebrafish fancl gene that causes homozygous mutants to develop as fertile males due to female-to-male sex ...
Asakawa, Kazuhide, BreMiller, Ruth A., Cañestro García, Cristian, Kawakami, Koichi, Nguyen-Johnson, Alexandria, Postlethwait, John H., Rodríguez Marí, Adriana   +6 more
core   +2 more sources

Applications of spatial transcriptomics in studying spermatogenesis

Andrology, Volume 13, Issue 5, Page 1181-1189, July 2025.
Abstract Spermatogenesis is a complex differentiation process that is facilitated by a series of cellular and molecular events. High‐throughput genomics approaches, such as single‐cell RNA sequencing, have begun to enable the systematic characterization of these events. However, the loss of tissue context because of tissue disassociations in the single‐
Qianlan Xu, Haiqi Chen
wiley   +1 more source

Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors.

PLoS ONE, 2010
Spermatogonia- stem cells and progenitors of adult spermatogenesis- are killed through a p53-regulated apoptotic process after gamma-irradiation but the death effectors are still poorly characterized.
Mathieu Coureuil, Nicolas Ugolin, Marie Tavernier, Sylvie Chevillard, Vilma Barroca, Pierre Fouchet, Isabelle Allemand   +6 more
doaj   +1 more source

Successful cryopreservation of spermatogonia in critically endangered Manchurian trout (Brachymystax lenok) [PDF]

, 2016
Because of the lack of cryopreservation techniques for fish eggs and embryos, 22 cryopreservation of fish spermatogonia and subsequent generation of eggs and sperm would be 23 an exit strategy for the long-term preservation of genetic resources.
Lee Seungki, Yoshizaki Goro
core   +2 more sources