Results 91 to 100 of about 1,004,483 (288)

Regulation of Endoplasmic Reticulum Stress-Autophagy: A Potential Therapeutic Target for Ulcerative Colitis

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic reticulum stress (ERS)-induced autophagy plays a vital role in the ...
Dan Qiao, Ziwei Zhang, Yali Zhang, Qian Chen, Yujun Chen, Yingjue Tang, Xiong Sun, Zhipeng Tang, Yancheng Dai   +8 more
doaj   +1 more source

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology

Cells, 2020
Parkinson’s disease (PD) is a multifactorial age-related movement disorder in which defects of both mitochondria and the endoplasmic reticulum (ER) have been reported.
C. D. Costa, Wejdane El Manaa, E. Duplan, F. Checler   +3 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Overexpression of factor VIII after AAV delivery is transiently associated with cellular stress in hemophilia A mice

Molecular Therapy: Methods & Clinical Development, 2016
Factor VIII (FVIII) is a large glycoprotein that is challenging to express both in vitro and in vivo. Several studies suggest that high levels of FVIII expression can lead to cellular stress.
Amy M Lange, Ekaterina S Altynova, Giang N Nguyen, Denise E Sabatino   +3 more
doaj   +1 more source

Unfolded Protein Response in Lung Health and Disease

Frontiers in Medicine, 2020
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats.
Nektarios Barabutis
doaj   +1 more source

IRE1-independent gain control of the unfolded protein response. [PDF]

PLoS Biology, 2004
Nonconventional splicing of the gene encoding the Hac1p transcription activator regulates the unfolded protein response (UPR) in Saccharomyces cerevisiae. This simple on/off switch contrasts with a more complex circuitry in higher eukaryotes.
Jess H Leber, Sebastián Bernales, Peter Walter   +2 more
doaj   +1 more source

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors [PDF]

, 2016
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds and
Callegari, Eduardo A., Chien, Jeremy, Drappeau, Donis D., Eyster, Kathleen M., Gamarra Luques, Carlos Diego, Goyeneche, Alicia A., Hapon, María Belén, Knapp, Jennifer R., Pan, Bo, Srinivasan, Rekha, Telleria, Carlos Marcelo, Terpstra, Erin J., Wang, Xuejun, Zhang, Lei   +13 more
core   +1 more source

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

eLife, 2016
HAC1 encodes a transcription factor that is the central effector of the unfolded protein response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an unspliced isoform in the cytoplasm and no Hac1 protein is detectable.
Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg   +2 more
doaj   +1 more source

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.

Cold Spring Harbor Perspectives in Biology, 2019
Most of the secreted and plasma membrane proteins are synthesized on membrane-bound ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident chaperones and foldases that assist in their folding and maturation.
G. E. Karagöz, D. Acosta-Alvear, P. Walter   +2 more
semanticscholar   +1 more source

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source