Results 211 to 220 of about 167,289 (308)

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Site‐Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting

Angewandte Chemie, EarlyView.
Using a mutational profiling approach an RNA‐targeted covalent probe was developed that is highly selective for the FMN riboswitch. The covalency was further supported by mass spectrometry experiments. The covalent probe selectively modifies the riboswitch at low micromolar concentrations within 10 min and remains functional when applied to an entire ...
Phillip Yesley, Georgia Poulladofonou, Danny Incarnato, Willem A. Velema   +3 more
wiley   +2 more sources

Cell-cell fusion limits activation of the unfolded protein response induced by the Nipah virus glycoproteins. [PDF]

J Virol
Jordan P, Heyer S, Hüther J, Fischer I, Becker N, Maisner A.   +5 more
europepmc   +1 more source

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis [PDF]

, 2015
Takahide Tohmonda, Masaki Yoda, Takao Iwawaki, Morio Matsumoto, Masaya Nakamura, Katsuhiko Mikoshiba, Yoshiaki Toyama, Keisuke Horiuchi   +7 more
openalex   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Plant rhabdovirus glycoprotein activates unfolded protein response-mediated antiviral ER-phagy in insect vectors. [PDF]

PLoS Pathog
Chen S, Cheng Y, Tang Y, Zhang J, Li Y, Jia D, Chen H, Wei T.   +7 more
europepmc   +1 more source

Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response

, 2011
Sara J.C. Gosline, Mirna Nascimento, Laura‐Isobel McCall, Dan Zilberstein, David Y. Thomas, Greg Matlashewski, Michael Hallett   +6 more
openalex   +2 more sources

A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer’s disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons

, 2020
Sanjib Guha, Sarah Fischer, Anson Cheng, Gail V.W. Johnson, Keith Nehrke   +4 more
openalex   +2 more sources

18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma [PDF]

, 2018
Jin Chen, Zhaoqi Zhang, Jia Song, Qiumeng Liu, Chao Wang, Zhao Huang, Liang Chu, Huifang Liang, Bixiang Zhang, Xiaoping Chen   +9 more
openalex   +1 more source