Results 111 to 120 of about 67,514 (293)

The unfolded protein response in multiple sclerosis

Frontiers in Neuroscience, 2015
The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj   +1 more source

Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention

Nature Communications, 2022
Chromatin remodeler Isw1 prevents export of maturing ribonucleoprotein particles. Here, the authors show that Isw1 inhibits the Unfolded Protein Response (UPR) from the nucleus by binding and restricting export of the mRNA encoding the main effector of ...
Laura Matabishi-Bibi, Drice Challal, Mara Barucco, Domenico Libri, Anna Babour   +4 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2020
The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
semanticscholar   +1 more source

The Unfolded Protein Response Supports Plant Development and Defense as well as Responses to Abiotic Stress [PDF]

, 2017
The unfolded protein response (UPR) is a stress response conserved in eukaryotic organisms and activated by the accumulation of misfolded proteins in the endoplasmic reticulum (ER).
Stephen H. Howell, Yan Bao
core   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic ...
Anna M. Kip, Joep Grootjans, Marco Manca, M’hamed Hadfoune, Bas Boonen, Joep P.M. Derikx, Erik A.L. Biessen, Steven W.M. Olde Damink, Cornelis H.C. Dejong, Wim A. Buurman, Kaatje Lenaerts   +10 more
doaj  

Conserved and Plant-Unique Strategies for Overcoming Endoplasmic Reticulum Stress

Frontiers in Plant Science, 2014
Stress caused by environmental conditions or physiological growth can lead to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) causing ER stress, which in turn triggers a cytoprotective mechanism termed the unfolded protein response
Cristina eRuberti, Cristina eRuberti, Federica eBrandizzi, Federica eBrandizzi   +3 more
doaj   +1 more source

The endoplasmic reticulum in plant immunity and cell death [PDF]

, 2012
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core   +2 more sources

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Bee Venom Induces Unfolded Protein Response in A172 Glioblastoma Cell Line [PDF]

, 2013
Background: Glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. Despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current ...
A Gutke, A Gutke, A Gutke, A Gutke, A Vleeming, Annelie Gutke, Birgitta Öberg, DC Cherkin, F Biering-Sorensen, F Turgut, HB Albert, HC Ostgaard, HO Svensson, HS Robinson, IM Mogren, J Brynhildsen, JC Fairbank, Jenny Sjödahl, JM Bastiaanssen, JM Mens, K Frändin, L Noren, NK Vollestad, P Enthoven, R Rabin, SM Wang, WH Wu   +26 more
core   +1 more source