Results 121 to 130 of about 8,105,112 (196)

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Emerging functions of the unfolded protein response in immunity

, 2014
The unfolded protein response (UPR) has traditionally been viewed as an adaptive response triggered by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) and aimed at restoring ER function.
Sophie Janssens, Lambrecht, Bart, Bali Pulendran, Pulendran, Bali, Bart N Lambrecht, Janssens, Sophie   +5 more
core   +1 more source

Single‐Cell Analysis of Cartilage‐Derived Cells Identifies Diverse Populations and a Cholesterol/ER‐Stress Chondrocyte Subset in Knee OA

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT This study aimed to elucidate the cellular and molecular mechanisms underlying knee osteoarthritis pathogenesis by analyzing chondrocyte populations and their spatial distribution using single‐cell RNA sequencing (scRNA‐seq). Knee cartilage cells underwent scRNA‐seq.
Yu Kobori, Kohei Nishitani, Hiroyuki Yoshitomi, Akinori Murakami, Kazuki Ichiyanagi, Shigeo Yoshida, Jiu Tanaka, Shinichi Kuriyama, Shinichiro Nakamura, Akio Sakamoto, Takashi Noguchi, Yugo Morita, Takashi Sono, Takayuki Fujii, Koichi Murata, Junya Toguchida, Hideki Ueno, Yasuhiro Murakawa, Chikashi Terao, Shuichi Matsuda   +19 more
wiley   +1 more source

Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein. [PDF]

Biomedicines, 2023
Keramidas P, Papachristou E, Papi RM, Mantsou A, Choli-Papadopoulou T.   +4 more
europepmc   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Cell death induction in <i>Aspergillus fumigatus</i>: accentuating drug toxicity through inhibition of the unfolded protein response (UPR). [PDF]

Curr Res Microb Sci, 2022
Guirao-Abad JP, Weichert M, Askew DS.
europepmc   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

an unfolded protein response

, 2019
Cholera toxin B subunit (CTB) exhibits broad‐spectrum biologic activity upon mucosal administration. Here, we found that a recombinant CTB containing an endoplasmic reticulum (ER) retention motif (CTB‐KDEL) induces colon epithelial wound healing in ...
Galandiuk, Susan, Oh, Young Jun, Nemencio Ronquillo, Lencer, Wayne I., Michael J. Grey, Wayne I. Lencer, Susan Galandiuk, Matoba, Nobuyuki, Ronquillo, Nemencio, Young Jun Oh, Royal, Joshua M., Joshua M. Royal, Grey, Michael J., Nobuyuki Matoba   +13 more
core   +1 more source

The mitochondrial unfolded protein response (UPR^mt) protects against osteoarthritis. [PDF]

Exp Mol Med, 2022
Zhou Z, Lu J, Yang M, Cai J, Fu Q, Ma J, Zhu L.   +6 more
europepmc   +1 more source

Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Plant lineage has traditionally constrained grafting compatibility, with monocots generally considered incompatible because of their dispersed vascular bundles and limited secondary growth. Recent studies have shown that embryonic grafting can establish successful graft unions in selected monocot systems by exploiting early developmental ...
Melagani Subash Chandra Gowda Sahaja, Melagani Subash Chandra Gowda Sahana, Revathi Thottathil, Chithra Rekha, Poomangalath Priyada, Vidhu Sankar Babu   +5 more
wiley   +1 more source