Results 101 to 110 of about 8,105,112 (196)

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment. [PDF]

Cancers (Basel), 2022
Bartoszewska S, Collawn JF, Bartoszewski R.   +2 more
europepmc   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

The mammalian unfolded protein response

, 2005
In the endoplasmic reticulum (ER) secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure.
Schröder, M., Kaufman, R.J.
core   +4 more sources

Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo. [PDF]

Methods Mol Biol, 2022
Katow H, Vasudevan D, Ryoo HD.
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress

EMBO Molecular Medicine, 2014
The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein response (UPR), a key mechanism ...
Samuel Lee, Soo Min Kim, James Dotimas, Letitia Li, Edward P Feener, Stephan Baldus, Ronald B Myers, William A Chutkow, Parth Patwari, Jun Yoshioka, Richard T Lee   +10 more
doaj   +1 more source

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR). [PDF]

Int J Mol Sci, 2022
Botrus G, Miller RM, Uson Junior PLS, Kannan G, Han H, Von Hoff DD.   +5 more
europepmc   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

Interplay between autophagy, the unfolded protein response and the cytoplasmic heat stress response during heat stress in maize

BMC Plant Biology
Background High temperatures can substantially reduce plant survival and reproduction, and therefore decrease crop productivity. Plants activate several pathways in response to high temperatures, including the endoplasmic reticulum (ER) unfolded protein ...
Jie Tang, Vishadinie Jayasinghe, Zhaoxia Li, Diane C. Bassham   +3 more
doaj   +1 more source

Mitochondrial unfolded protein response [PDF]

, 2016
Mitochondrion is an organelle of the eukaryotic cell responsible for the crucial metabolic processes and the apoptosis. Therefore, it is necessary for the survival of the cell to maintain mitochondrial functionality. Hence, the mitochondria have specific
Zemanová, Tereza
core