Results 51 to 60 of about 2,762,413 (264)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

On the moments of random variables uniformly distributed over a polytope

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1997
Suppose X=(X1,X2,…,Xn) is a random vector uniformly distributed over a polytope. In this note, the author derives a formula for E(XirXjs…), (the expected value of XirXjs…), in terms of the extreme points of the polytope.
S. Paramasamy
doaj   +1 more source

Some limit theorems for ratios of order statistics from uniform random variables

open access: yesJournal of Inequalities and Applications, 2017
In this paper, we study the ratios of order statistics based on samples drawn from uniform distribution and establish some limit properties such as the almost sure central limit theorem, the large deviation principle, the Marcinkiewicz-Zygmund law of ...
Shou-Fang Xu, Yu Miao
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Natural Test for Random Numbers Generator Based on Exponential Distribution

open access: yesMathematics, 2019
We will prove that when uniformly distributed random numbers are sorted by value, their successive differences are a exponentially distributed random variable Ex(λ).
Ilija Tanackov   +6 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Effects of Random Values for Particle Swarm Optimization Algorithm

open access: yesAlgorithms, 2018
Particle swarm optimization (PSO) algorithm is generally improved by adaptively adjusting the inertia weight or combining with other evolution algorithms.
Hou-Ping Dai   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

On strong uniform distribution IV

open access: yesJournal of Inequalities and Applications, 2005
Let be a strictly increasing sequence of natural numbers and let be a space of Lebesgue measurable functions defined on . Let denote the fractional part of the real number . We say that is an sequence if for each we set , then , almost everywhere
Nair R
doaj  

On the uniformity of distribution of Farey fractions

open access: yesLietuvos Matematikos Rinkinys, 2009
Let F x be the set of nonnegative rationals m\n with 0 < n
Vilius Stakėnas
doaj   +1 more source

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