Results 41 to 50 of about 12,810 (206)

Magnetoliposomes as model for signal transmission [PDF]

Royal Society Open Science, 2019
Liposomes containing magnetic nanoparticles (magnetoliposomes) have been extensively explored for targeted drug delivery. However, the magnetic effect of nanoparticles movement is also an attractive choice for the conduction of signals in communication ...
G. R. Barreto, C. Kawai, A. Tofanello, A. A. R. Neves, J. C. Araujo-Chaves, E. Belleti, A. J. C. Lanfredi, F. N. Crespilho, I. L. Nantes-Cardoso   +8 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow

Advanced Materials Interfaces, EarlyView.
A biomimetic venous circulation system is developed to study protein corona formation on soft nanocarriers under physiological shear. Liposomes, PLGA nanoparticles, and lipid‐polymer hybrid nanoparticles acquire largely shared but material‐dependent protein coronas that alter surface properties and suppress cellular uptake, highlighting the importance ...
Anamarija Nikoletić, Dominik Simon Müller, Timon Flathmann, Jakob Steuer, Evangelos Natsaridis, Chiara Candino, Abdullah Kahraman, Oya Tagit   +7 more
wiley   +1 more source

SIMPLE AND FAST PROCEDURE TO INCORPORATE DOXORUBICINE IN SMALL UNILAMELLAR LIPOSOMES: EFFECTS ON LIPOSOME SIZE AND ZETA POTENTIAL

Studia Universitatis Babes-Bolyai Chemia, 2019
This study aimed to find alternative, cheap and fast procedures to incorporate Doxorubicin in small unilamellar nanoliposomes made of Dipalmitoyl Phosphatidyl Choline and Cholesterol. It was compared the entrapment efficiency of doxorubicin in home-made
Mihai Adrian SOCACIU, Zorita DIACONEASA, Carmen SOCACIU   +2 more
doaj   +1 more source

Formulation and evaluation of baclofen liposome vesicles using lecithin

Ars Pharmaceutica, 2020
Introduction: The main aim of present study was to prepare and characterize liposomal formulation of baclofen to improve the effectiveness of the topically applied formulation.
Raj K. Keservani, Surya Prakash Gautam
doaj   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers

Marine Drugs, 2017
Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes.
Tadeusz F. Molinski, Caroline D. Broaddus, Brandon I. Morinaka   +2 more
doaj   +1 more source

Describing the SAXS Profile of Unilamellar Liposomes via Beating Waves [PDF]

, 2023
Laura Baraldi, Serena Rosa Alfarano, Flávia Sousa, Raffaele Mezzenga, Barbara Rothen-Rutishaser, Alke Petri‐Fink, Sandor Balog   +6 more
openalex   +1 more source