Results 71 to 80 of about 588,405 (243)

Universal Wave-Function Overlap and Universal Topological Data from Generic Gapped Ground States

open access: yesPhysical Review Letters, 2015
We propose a way -- universal wave function overlap -- to extract universal topological data from generic ground states of gapped systems in any dimensions. Those extracted topological data should fully characterize the topological orders with gapped or gapless boundary. For non-chiral topological orders in 2+1D, this universal topological data consist
Moradi, Heidar, Wen, Xiao-Gang
openaire   +5 more sources

Bethe ansatz solution of zero-range process with nonuniform stationary state

open access: yes, 2004
The eigenfunctions and eigenvalues of the master-equation for zero range process with totally asymmetric dynamics on a ring are found exactly using the Bethe ansatz weighted with the stationary weights of particle configurations.
A. M. Povolotsky   +9 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Optimal length and signal amplification in weakly activated signal transduction cascades

open access: yes, 2003
Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena   +2 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Replica approach to the generalized Rosenzweig-Porter model

open access: yesSciPost Physics, 2023
The generalized Rosenzweig-Porter model with real (GOE) off-diagonal entries arguably constitutes the simplest random matrix ensemble displaying a phase with fractal eigenstates, which we characterize here by using replica methods.
Davide Venturelli, Leticia F. Cugliandolo, Grégory Schehr, Marco Tarzia
doaj   +1 more source

Non-equilibrium spin-boson model: counting statistics and the heat exchange fluctuation theorem

open access: yes, 2011
We focus on the non-equilibrium two-bath spin-boson model, a toy model for examining quantum thermal transport in many-body open systems. Describing the dynamics within the NIBA equations, applicable, e.g., in the strong system-bath coupling limit and/or
Nicolin, Lena, Segal, Dvira
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Modelling and evaluation of multi-state reliability of repairable non-series manufacturing system with finite buffers

open access: yesAdvances in Mechanical Engineering, 2019
The capacity and capability of flexible manufacturing system varies with different market demands. To satisfy the requirements of performance expressions, avoid the problem of combinatorial explosion and consider the influence of intermediate buffer ...
Jianguo Duan, Nan Xie, Lianhui Li
doaj   +1 more source

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