Results 121 to 130 of about 50,051 (221)

A Novel Murine Model of Hemophagocytic Lymphohistiocytosis‐Like Inflammation in ZNFX1 Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
LCMV‐infected Znfx1‐deficient mice develop hemophagocytic lymphohistiocytosis (HLH)‐like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1‐deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages ...
Diana Tintor, Samantha Milanesi, Tommaso Marchetti, Tiziana Lorenzini, Severin Walser, Junyi Chen, Julius Köppen, Achim Weber, Ola Sabet, Jana Pachlopnik Schmid   +9 more
wiley   +1 more source

Chasing Seasonal Influenza — The Need for a Universal Influenza Vaccine

New England Journal of Medicine, 2018
Chasing Seasonal Influenza As we prepare for a potentially severe influenza season, we must consider whether our current vaccines can be improved and whether longer-term, transformative vaccine approaches are needed to minimize influenza-related morbidity and mortality.
Catharine I, Paules, Sheena G, Sullivan, Kanta, Subbarao, Anthony S, Fauci   +3 more
openaire   +2 more sources

Inactivated recombinant influenza vaccine: the promising direction for the next generation of influenza vaccine

Expert Review of Vaccines
Introduction Vaccination is the most effective method to control the prevalence of seasonal influenza and the most widely used influenza vaccine is the inactivated influenza vaccine (IIV).
Hua Shi, Ted M. Ross
doaj   +1 more source

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice [PDF]

, 2019
Background: Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antigenic alterations occur during ...
Aerts, Joeri, Christopoulou, Ioanna, Heirman, Carlo, Joe, Patrick Tjok, Saelens, Xavier, Schepens, Bert, Thielemans, Kris, Van Hoecke, Lien, Ysenbaert, Tine   +8 more
core   +2 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. [PDF]

, 2012
BackgroundThe recent emergence of the 2009 pandemic influenza A/H1N1 virus has highlighted the value of free and open access to influenza virus genome sequence data integrated with information about other important virus characteristics.DesignThe ...
Baumgarth, Nicole, Deitrich, Jon, García-Sastre, Adolfo, Hunt, Victoria, Klem, Edward, Kumar, Sanjeev, Larsen, Christopher N, Macken, Catherine, Noronha, Jyothi, Pickett, Brett E, Ramsey, Alvin, Scheuermann, Richard H, Squires, R Burke, Suarez, David, Zaremba, Sam, Zhang, Yun, Zhou, Liwei   +16 more
core   +1 more source

Distinct 5′ UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses

Microbiology and Immunology, Volume 70, Issue 2, Page 80-90, February 2026.
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Meng‐Chi Wu, Takehiro Kanda, Ryo Komorizono, Madoka Sakai, Alexander Leacy, Leonardo Susta, Akiko Makino, Keizo Tomonaga   +7 more
wiley   +1 more source

Universal Oral Vaccine for Influenza Infections

Jurnal Sains Kesihatan Malaysia, 2018
Each year, influenza A infections have caused tremendous death rate as high as 300,000-500,000 globally. Although there are effective anti-influenza agents and vaccines, high mutational rate among influenza A viruses renders dramatic decline in the effectiveness of anti-influenza agents or vaccines in certain individuals.
WEI BOON YAP, SENG TAN TOONG, SHARIFAH SYED HASSAN   +2 more
openaire   +1 more source

Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. [PDF]

, 2006
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a clinical syndrome that has an ever-growing list of potential causes. The transfusion of blood products is often a life-saving therapy, but it can be associated with the development of ...
Looney, Mark R
core   +1 more source

Factors associated with influenza vaccine uptake during a universal vaccination programme of preschool children in England and Wales: a cohort study [PDF]

, 2016
INTRODUCTION: Influenza vaccination through primary care has been recommended for all preschool children in the UK since 2013 as part of a universal immunisation programme. Vaccination is required annually and effectiveness varies by season.
Gilbert, R, Hardelid, P, Petersen, I, Rait, G   +3 more
core   +1 more source