Results 81 to 90 of about 50,051 (221)

Development and characterization of influenza M2 ectodomain and/or hemagglutinin stalk-based dendritic cell-targeting vaccines

Frontiers in Microbiology, 2022
A universal influenza vaccine is required for broad protection against influenza infection. Here, we revealed the efficacy of novel influenza vaccine candidates based on Ebola glycoprotein dendritic cell (DC)-targeting domain (EΔM) fusion protein ...
Titus Abiola Olukitibi, Titus Abiola Olukitibi, Zhujun Ao, Zhujun Ao, Hiva Azizi, Mona Mahmoudi, Mona Mahmoudi, Kevin Coombs, Darwyn Kobasa, Darwyn Kobasa, Gary Kobinger, Gary Kobinger, Xiaojian Yao, Xiaojian Yao   +13 more
doaj   +1 more source

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]

, 2018
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon, D. Ann Herring, David J. D. Earn, Enrique Acosta, Joaquin Madrenas, Kris Inwood, Lisa Y. Dillon, Matthew S. Miller, Nadine Ouellette, Robert Bourbeau, Stacey Hallman, W. Ian Lipkin   +11 more
core   +3 more sources

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Incidence and viral aetiologies of acute respiratory illnesses (ARIs) in the United States: a population-based study. [PDF]

, 2016
We conducted prospective, community-wide surveillance for acute respiratory illnesses (ARIs) in Rochester, NY and Marshfield, WI during a 3-month period in winter 2011.
Albertin, C, Blumkin, A, Donahue, JG, Gallivan, S, Lofthus, GK, Schnabel, KC, Shay, DK, Szilagyi, PG, Thompson, MG, Treanor, JJ   +9 more
core   +1 more source

Maternal RSV vaccination for infant protection: A systematic review and meta‐analysis of phase 3 trials with an integrated economic evaluation

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Respiratory syncytial virus (RSV) is a leading cause of hospitalization and mortality in early infancy. Maternal immunization offers a preventive strategy, but uncertainties regarding safety and economic value have limited its implementation.
Johnatan Torres‐Torres, Lourdes Rojas‐Zepeda, José Rafael Villafan‐Bernal, Raigam Martinez‐Portilla, Salvador Espino‐y‐Sosa, Pablo Cerda‐Flores, Elsa Romelia Moreno‐Verduzco, Irma Eloisa Monroy‐Muñoz, Ameyran Yolanda Gonzalez‐Guerrero, Juan Mario Solis‐Paredes, Javier Perez Duran   +10 more
wiley   +1 more source

M2e-based universal influenza vaccines: a historical overview and new approaches to development

Journal of Biomedical Science, 2019
The influenza A virus was isolated for the first time in 1931, and the first attempts to develop a vaccine against the virus began soon afterwards. In addition to causing seasonal epidemics, influenza viruses can cause pandemics at random intervals ...
Daria Mezhenskaya, Irina Isakova-Sivak, Larisa Rudenko   +2 more
doaj   +1 more source

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age [PDF]

, 2014
Background: Vaccines against pandemic A/H1N1 influenza should provide protective immunity in children, because they are at greater risk of disease than adults.
Abarca, Katia, Arora, Ashwani, Della Cioppa, Giovanni, Kieninger-Baum, Dorothee, Knuf, Markus, Lattanzi, Maria, Leroux-Roels, Geert, Pedotti, Paola, Rivera, Luis, Rümke, Hans C   +9 more
core   +2 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Computational Approaches and Challenges to Developing Universal Influenza Vaccines

Vaccines, 2019
The traditional design of effective vaccines for rapidly-evolving pathogens, such as influenza A virus, has failed to provide broad spectrum and long-lasting protection. With low cost whole genome sequencing technology and powerful computing capabilities,
Xueting Qiu, Venkata R. Duvvuri, Justin Bahl   +2 more
doaj   +1 more source

Robust immunity and heterologous protection against influenza in mice elicited by a novel recombinant NP-M2e fusion protein expressed in E. coli. [PDF]

PLoS ONE, 2012
BACKGROUND: The 23-amino acid extracellular domain of matrix 2 protein (M2e) and the internal nucleoprotein (NP) of influenza are highly conserved among viruses and thus are promising candidate antigens for the development of a universal influenza ...
Wenling Wang, Baoying Huang, Tao Jiang, Xiuping Wang, Xiangrong Qi, Yingying Gao, Wenjie Tan, Li Ruan   +7 more
doaj   +1 more source