Results 61 to 70 of about 50,247 (212)

Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge

Viruses, 2021
The development of an influenza vaccine with broad protection and durability remains an attractive idea due to the high mutation rate of the influenza virus.
Daria Mezhenskaya, Irina Isakova-Sivak, Victoria Matyushenko, Svetlana Donina, Andrey Rekstin, Konstantin Sivak, Kirill Yakovlev, Anastasia Katelnikova, Kirill Kryshen, Valery Makarov, Larisa Rudenko   +10 more
doaj   +1 more source

End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17 [PDF]

, 2017
Introduction The United Kingdom is in the fourth season of introducing a universal childhood influenza vaccine programme. The 2016/17 season saw early influenza A(H3N2) virus circulation with care home outbreaks and increased excess mortality ...
Andrews, Nick, Correa, Ana, Cottrell, Simon, de Lusignan, Simon, Ellis, Joanna, Galiano, Monica, Gallagher, Naomh, Gunson, Rory, McMenamin, Jim, Moore, Catherine, Pebody, Richard, Potts, Alison, Reynolds, Arlene, Robertson, Chris, Sartaj, Muhammad, Sinnathamby, Mary, Thompson, Catherine, Warburton, Fiona, Yonova, Ivelina, Zambon, Maria   +19 more
core   +1 more source

Advances in the development of universal influenza vaccines [PDF]

Influenza and Other Respiratory Viruses, 2012
Please cite this paper as: Sarah C. Gilbert. (2012) Advances in the development of universal influenza vaccines. Influenza and Other Respiratory Viruses DOI:10.1111/irv.12013.Despite the widespread availability and use of influenza vaccines, influenza still poses a considerable threat to public health.
openaire   +2 more sources

Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin. [PDF]

, 2018
To overcome yearly efforts and costs for the production of seasonal influenza vaccines, new approaches for the induction of broadly protective and long-lasting immune responses have been developed in the past decade. To warrant safety and efficacy of the
Farinelle, S, Hauck, NC, He, FQ, Kiefer, C, Kirpach, J, Lu, I-N, Maucourant, S, Morris, SA, Muller, CP, Rosenberg, W   +9 more
core   +2 more sources

Prospects for Universal Influenza Virus Vaccine

Emerging Infectious Diseases, 2006
The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by the vaccine. A vaccine that is less sensitive to the antigenic evolution of the virus would be a major improvement.
Walter Gerhard, Krystyna Mozdzanowska, Darya Zharikova   +2 more
openaire   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [PDF]

, 2014
There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic ...
Achilefu, Samuel, Chen, Alexander, Donthi, Nisha, Hsieh, Wen-Han, Hung, Chien-Fu, Knoff, Jayne, La, Victor, Li, Yen-Der, Tsen, Kong-Thon, Tsen, Shaw-Wei David, Wu, Tzyy-Choou   +10 more
core   +2 more sources

A Perspective on Nanoparticle Universal Influenza Vaccines

ACS Infectious Diseases, 2018
Annually recurring seasonal influenza causes massive economic loss and poses severe threats to public health worldwide. The current seasonal influenza vaccines are the most effective means of preventing influenza infections but possess major weaknesses. Seasonal influenza vaccines require annual updating of the vaccine strains.
Lei Deng, Bao-Zhong Wang
openaire   +3 more sources

Towards universal influenza vaccines? [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement.
A. Osterhaus, R. Fouchier, G. Rimmelzwaan   +2 more
openaire   +3 more sources

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source